期刊
AGE AND AGEING
卷 51, 期 3, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/ageing/afac058
关键词
falls; multiple falls; cognitive decline; the Motoric Cognitive Risk syndrome; dementia; older people
资金
- National Institute of Health/National Institute on Aging [PO1AG03949, R01AG057548-01A1]
Multiple falls may be an important marker to identify older people at greater risk of future cognitive decline and incident MCR.
Background falls share risk factors with cognitive decline but whether falls predict cognitive decline, pre-dementia syndromes and dementia is poorly understood. Objectives this study aimed to examine if falls are associated with cognitive decline in specific domains and the risk of Motoric Cognitive Risk (MCR) syndrome and dementia. Design cross-sectional study. Methods in older people (age 80.6 +/- 5.3 years) free of dementia at baseline, the number of falls (none, one or multiple) during the year before enrolment and the first year of follow-up (exposure) were recorded. Decline in specific cognitive functions (global cognition, episodic verbal memory, verbal fluency, working memory, response inhibition and processing speed-attention), incident MCR and incident dementia were outcome measures. Linear mixed effects models were used to examine the associations between falls and cognitive decline, adjusting for confounders. Cox proportional hazards models were used to determine if falls predicted risk of incident MCR or dementia. Results of 522 eligible participants, 140 had a single fall and 70 had multiple falls. Multiple falls were associated with a greater decline in global cognition, episodic memory, verbal fluency and processing speed-attention compared to those with no falls (P < 0.05). Over a median follow-up of 1.0 years 36 participants developed MCR and 43 participants developed dementia. Those with multiple falls had a two-fold increased risk of MCR compared to those with no falls, but no increased risk of developing dementia. Conclusions multiple falls may be an important marker to identify older people at greater risk of future cognitive decline and incident MCR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据