期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 364, 期 10, 页码 1701-1707出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202200154
关键词
1,2-dicarbofunctionalization; borata-alkene; tertiary boronic esters; tertiary alcohols; cyclopropanation
资金
- Ministerio de Economia y Competitividad
- Fondo Europeo de Desarrollo Regional FEDER [PID2019-109674GB-I00]
This article describes the conjugate addition of tert-butyllithium to vinyl systems of boronic esters to generate a borata-alkene intermediate, followed by a sequential S(N)2 reaction with alkyl halides, at room temperature. The reaction retains all the carbon atoms from the three starting materials involved in the assembly.
We describe here the conjugate addition of tert-butyllithium to vinyl systems of boronic esters to generate a borata-alkene intermediate, followed by a sequential S(N)2 reaction with alkyl halides, at room temperature. We envisioned this goal through engaged C(sp(3)) chemical entities avoiding metal catalysts, additives, radical initiators or specific irradiation. This reaction guarantees that the new tetrasubstituted carbon formed retains all the C atoms from the three starting materials involved in the assembly.
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