2-Bromo-3,3,3-Trifluoropropene: A Versatile Reagent for the Synthesis of Fluorinated Compounds

2-Bromo-3,3,3-trifluoropropene (BTP) represents a highly valuable synthon in synthetic chemistry, and has been widely used in organic synthesis, mainly including addition reactions, cross-coupling reactions, cycloaddition or cyclization reactions, S(N)2' reactions, and Stetter reactions for the construction of various fluorinated organic compounds. In this review, we systematically summarize these reactions; their mechanisms are also discussed.

Automated summary

In this review, we systematically summarize the applications of 2-bromo-3,3,3-trifluoropropene (BTP) in organic synthesis, including addition reactions, cross-coupling reactions, cycloaddition or cyclization reactions, S(N)2' reactions, and Stetter reactions, and discuss their mechanisms.