Preparation of poly(e-lysine)-cyclodextrin coated Fe3O4 nanoparticles for selective separation of natural medicine: Scutellarin

In the present study, poly(e-lysine)-cyclodextrin coated Fe3O4 nanoparticles (PL-CD@Fe3O4) were prepared by co-precipitation method. Then the PL-CD@Fe3O4 nanoparticles were studied of the characterization and the selective separation performance for natural medicine (scutellarin). The experimental results showed that PL-CD@Fe3O4 nanoparticles were successfully prepared with a particle size of about 30 nm and a saturation magnetization of 40 emu/g. When the nanoparticles were in the environment of pH = 7, the stability was the best, the adsorption capacity was the strongest, and the number of recyclable times was the most. Langmuir model deduced that the maximum adsorption capacity of the nanoparticles was 76.3 mg/g. In addition, the experimental results of using nanoparticles to separate SCU in the crude extract showed that the purity of SCU could be increased from 72.2% to 93.5% after repeated cyclic separation three times. Two dimensional NMR analysis showed that the selective separation of SCU by PL-CD@Fe3O4 was mainly caused by the host-guest interaction between cyclodextrin and SCU. In conclusion, the PL-CD@Fe3O4 nanoparticles are a very promising material for the extraction and separation of other similar natural drugs. (C)& nbsp;2022 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.

Automated summary

In this study, poly(e-lysine)-cyclodextrin coated Fe3O4 nanoparticles (PL-CD@Fe3O4) were successfully prepared and their selective separation performance for natural medicine scutellarin was investigated. The experimental results showed that the nanoparticles had good stability and strong adsorption capacity, leading to increased purity of scutellarin during the separation process.