High-Precision Micropatterning of Polydopamine by Multiphoton Lithography

Mussel-inspired polydopamine (PDA) initiates a multifunctional modification route that leads to the generation of novel advanced materials and their applications. However, existing PDA deposition techniques still exhibit poor spatial control, have a very limited capability of micropatterning, and do not allow local tuning of the PDA topography. Herein, PDA deposition based on multiphoton lithography (MPL) is demonstrated, which enables full spatial and temporal control with nearly total freedom of patterning design. Using MPL, 2D microstructures of complex design are achieved with pattern precision of 0.8 mu m without the need of a photomask or stamp. Moreover, this approach permits adjusting the morphology and thickness of the fabricated microstructure within one deposition step, resulting in a unique tunability of material properties. The chemical composition of PDA is confirmed and its ability for protein enzyme immobilization is demonstrated. This work presents a new methodology for high-precision and complete control of PDA deposition, enabling PDA incorporation in applications where fine and precise local surface functionalization is required. Possible applications include multicomponent functional elements and devices in microfluidics or lab-on-a-chip systems.

Automated summary

This study demonstrates a PDA deposition method based on multiphoton lithography, which enables full control over spatial and temporal aspects, and allows for flexible pattern design. 2D microstructures with complex designs are achieved with high pattern precision, and the morphology and thickness of the fabricated microstructure can be adjusted within one deposition step, providing tunability of material properties. This work introduces a new method for high-precision and complete control of PDA deposition, enabling its incorporation in applications that require fine and precise local surface functionalization.