期刊
ADVANCED FUNCTIONAL MATERIALS
卷 32, 期 25, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202200908
关键词
dual-bionic multinetwork hydrogels; multimodal self-healing; nonpressing porcine hemostasis; promoted wound healing; repeatable wet-tissue adhesion
类别
资金
- National Key R&D Program of China [2021YFC2400600/2021YFC2400604]
- National Natural Science Foundation of China [51903050, 21874024]
- Major Project of Science and Technology of Fujian Province [2020HZ06006]
- Natural Science Foundation of Fujian Province [2019J01258]
- Key Program of Qingyuan Innovation Laboratory [00221002]
- Fuzhou University Testing Fund of Precious Apparatus [2021T025]
- Top Young Talents of Foal Eagle Program of Fujian Province
- Youth Promotion Talent Project of Fujian Province
A dual-bionic hydrogel inspired by mussel and barnacle cement proteins is proposed, which shows excellent adhesiveness, antibacterial properties, and potential for rapid hemostasis and wound healing.
Massive bleeding and wound infection are the major problems often observed during severe trauma, and achieving rapid hemostasis in cases of high-dose bleeding in arteries and viscera remains an acute clinical demand. Herein, a mussel- and barnacle cement proteins-inspired dual-bionic hydrogel is first proposed. Benefiting from abundant phenolic hydroxyl groups, a tough dissipative matrix, removal of interfacial water, as well as dynamic redox balance of phenol-quinone, the multinetwork hydrogel achieves repeatable robust wet-tissue adhesiveness (151.40 +/- 1.50 kPa), a fast multimodal self-healing ability, and excellent antibacterial property against both Gram-positive/negative bacteria. For rabbit/pig models of cardiac penetration holes and femoral artery injuries, the dual-bionic bioadhesive shows better hemostatic efficiency than commercial gauze due to the synergistic effect of strong wound sealing capability, excellent red blood cell capturing property, and activation of hemostatic barrier membrane. More interestingly, the hydrogel combined with commercial hemostatic sponge presents accelerated wound healing as well as great potential for treating deep-wound hemorrhage in a battlefield environment. Overall, owing to these unique advantages, the novel tissue-adhesive hemostat opens up a new avenue to rapid sealing hemostasis and wound healing applications.
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