期刊
ADVANCED FUNCTIONAL MATERIALS
卷 32, 期 32, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202203533
关键词
bone healing; diagnostic; energy harvesting; medical implant; metamaterial; triboelectric nanogenerators
类别
资金
- National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [R21AR075242-01]
- Swanson School of Engineering at the University of Pittsburgh
This paper discusses the unmet need for smart medical implants and proposes the concept of self-aware implants to create a new generation of multifunctional metamaterial implantable devices. The integration of nano energy harvesting and mechanical metamaterial design paradigms enables these implants to respond to their environment, empower themselves, and self-monitor their condition.
There is an unmet need for developing a new class of smart medical implants with novel properties and advanced functionalities. Here, the concept of self-aware implants is proposed to enable the creation of a new generation of multifunctional metamaterial implantable devices capable of responding to their environment, empowering themselves, and self-monitoring their condition. These functionalities are achieved via integrating nano energy harvesting and mechanical metamaterial design paradigms. Various aspects of the proposed concept are highlighted by developing proof-of-concept interbody spinal fusion cage implants with self-sensing, self-powering, and mechanical tunability features. Bench-top testing is performed using synthetic biomimetic and human cadaver spine models to evaluate the electrical and mechanical performance of the developed patient-specific metamaterial implants. The results show that the self-aware cage implants can diagnose bone healing process using the voltage signals generated internally through their built-in contact-electrification mechanisms. The voltage and current generated by the implants under the axial compression forces of the spine models reach 9.2 V and 4.9 nA, respectively. The metamaterial implants can serve as triboelectric nanogenerators to empower low-power electronics. The capacity of the proposed technology to revolutionize the landscape of implantable devices and to achieve better surgical outcomes is further discussed.
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