4.7 Review

Breaking through the barrier: Modelling and exploiting the physical microenvironment to enhance drug transport and efficacy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Endocrinology & Metabolism

Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model

Ana R. Santa-Maria et al.

Summary: This study investigated the properties of the blood-brain barrier and glycocalyx in human-like brain endothelial cells (BLECs) using a microfluidic lab-on-a-chip device under dynamic conditions. The results showed that fluid flow regulated the expression of endothelial, BBB, and glycocalyx genes, leading to increased barrier properties and a more negative surface charge of BLECs. The study highlights the importance of fluid flow in maintaining the physiological functions of the BBB in culture models.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

Article Multidisciplinary Sciences

Transcriptome comparisons of in vitro intestinal epithelia grown under static and microfluidic gut-on-chip conditions with in vivo human epithelia

Kornphimol Kulthong et al.

Summary: Dynamic culture conditions in gut-on-chip devices can mimic the in vivo intestinal environment and impact the gene expression of Caco-2 cells. The study shows that under dynamic culture conditions, gene expression patterns similar to those of the intestines in vivo were observed.

SCIENTIFIC REPORTS (2021)

Article Biology

Lectin Staining of Microvascular Glycocalyx in Microfluidic Cancer Cell Extravasation Assays

Sebastian Beyer et al.

Summary: This study utilized staining techniques to observe the process of breast cancer cell extravasation in 3D microfluidic cell cultures, highlighting the role of the endothelial glycocalyx and its defects on cancer cell extravasation.

LIFE-BASEL (2021)

Article Biochemistry & Molecular Biology

Matrix stiffness modulates ILK-mediated YAP activation to control the drug resistance of breast cancer cells

Xiang Qin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

Review Nanoscience & Nanotechnology

The stiffness of living tissues and its implications for tissue engineering

Carlos F. Guimaraes et al.

NATURE REVIEWS MATERIALS (2020)

Article Multidisciplinary Sciences

A dynamic perfusion based blood-brain barrier model for cytotoxicity testing and drug permeation

Basma Elbakary et al.

SCIENTIFIC REPORTS (2020)

Review Biochemistry & Molecular Biology

Fibrosis and cancer: A strained relationship

Bram Piersma et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

Review Physiology

Mechanisms Ensuring Endothelial Junction Integrity Beyond VE-Cadherin

Cao Nguyen Duong et al.

FRONTIERS IN PHYSIOLOGY (2020)

Article Multidisciplinary Sciences

Temporal pressure enhanced topical drug delivery through micropore formation

Daniel Chin Shivan Lio et al.

SCIENCE ADVANCES (2020)

Review Physiology

Fluid Shear Stress Sensing by the Endothelial Layer

Etienne Roux et al.

FRONTIERS IN PHYSIOLOGY (2020)

Editorial Material Physiology

Shearing the brain

Jay M. J. R. Carr et al.

JOURNAL OF APPLIED PHYSIOLOGY (2020)

Review Biotechnology & Applied Microbiology

Design and Application in Delivery System of Intranasal Antidepressants

Jingying Xu et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Article Biochemical Research Methods

Dynamic in vitro intestinal barrier model coupled to chip-based liquid chromatography mass spectrometry for oral bioavailability studies

Milou J. C. Santbergen et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Acetaminophen absorption and metabolism in an intestine/liver microphysiological system

Talita Miguel Marin et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2019)

Article Multidisciplinary Sciences

Astrocytic endfeet re-cover blood vessels after removal by laser ablation

Hideaki Kubotera et al.

SCIENTIFIC REPORTS (2019)

Article Biochemical Research Methods

Penetration and Uptake of Nanoparticles in 3D Tumor Spheroids

Aleksandra Tchoryk et al.

BIOCONJUGATE CHEMISTRY (2019)

Review Physiology

PASSING THE VASCULAR BARRIER: ENDOTHELIAL SIGNALING PROCESSES CONTROLLING EXTRAVASATION

Nina Wettschureck et al.

PHYSIOLOGICAL REVIEWS (2019)

Article Biochemical Research Methods

Quantifying blood-brain-barrier leakage using a combination of evans blue and high molecular weight FITC-Dextran

Yangyang Xu et al.

JOURNAL OF NEUROSCIENCE METHODS (2019)

Article Biochemistry & Molecular Biology

Development of a Gut-on-a-Chip Model for High Throughput Disease Modeling and Drug Discovery

Claudia Beaurivage et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biophysics

The Effect of Charge and Mechanical Loading on Antibody Diffusion Through the Articular Surface of Cartilage

Chris D. DiDomenico et al.

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME (2019)

Article Nanoscience & Nanotechnology

Spatially Uniform Tumor Treatment and Drug Penetration by Regulating Ultrasound with Microbubbles

Yi-Ju Ho et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Review Cell & Tissue Engineering

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

Kacey Ronaldson-Bouchard et al.

CELL STEM CELL (2018)

Article Cell & Tissue Engineering

Decoupling the Effect of Shear Stress and Stretch on Tissue Growth and Remodeling in a Vascular Graft

Eline E. van Haaften et al.

TISSUE ENGINEERING PART C-METHODS (2018)

Article Multidisciplinary Sciences

Enhanced nasal drug delivery efficiency by increasing mechanical loading using hypergravity

Dongjoo Kim et al.

SCIENTIFIC REPORTS (2018)

Article Biochemical Research Methods

Human stomach-on-a-chip with luminal flow and peristaltic-like motility

Kang Kug Lee et al.

LAB ON A CHIP (2018)

Article Multidisciplinary Sciences

Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption

Costas D. Arvanitis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Cell Biology

Restriction of drug transport by the tumor environment

Rajender Nandigama et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2018)

Article Gastroenterology & Hepatology

Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips

Michael J. Workman et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2018)

Review Gastroenterology & Hepatology

Microfluidic Organ-on-a-Chip Models of Human Intestine

Amir Bein et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2018)

Article Biotechnology & Applied Microbiology

Microfluidic Blood-Brain Barrier Model Provides In Vivo-Like Barrier Properties for Drug Permeability Screening

Ying I. Wang et al.

BIOTECHNOLOGY AND BIOENGINEERING (2017)

Article Endocrinology & Metabolism

Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium

Fernando Garcia-Polite et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017)

Review Gastroenterology & Hepatology

The intestinal epithelial barrier: a therapeutic target?

Matthew A. Odenwald et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Article Biochemistry & Molecular Biology

Solute Carriers in the Blood-Brain Barier: Safety in Abundance

Katarzyna A. Nalecz

NEUROCHEMICAL RESEARCH (2017)

Review Endocrinology & Metabolism

The vascular basement membrane in the healthy and pathological brain

Maj S. Thomsen et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017)

Article Rheumatology

Cartilage-targeting drug delivery: can electrostatic interactions help?

Ambika G. Bajpayee et al.

NATURE REVIEWS RHEUMATOLOGY (2017)

Article Multidisciplinary Sciences

Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions

Yongzhi Qiu et al.

NATURE COMMUNICATIONS (2017)

Article Materials Science, Biomaterials

Intestine-on-a-Chip Microfluidic Model for Efficient in Vitro Screening of Oral Chemotherapeutic Uptake

Kyall Pocock et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2017)

Article Materials Science, Biomaterials

Intestine-on-a-Chip Microfluidic Model for Efficient in Vitro Screening of Oral Chemotherapeutic Uptake

Kyall Pocock et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2017)

Article Engineering, Biomedical

Mechanical stress regulates transport in a compliant 3D model of the blood-brain barrier

Paul P. Partyka et al.

BIOMATERIALS (2017)

Review Oncology

Transport of drugs from blood vessels to tumour tissue

Mark W. Dewhirst et al.

NATURE REVIEWS CANCER (2017)

Review Biochemistry & Molecular Biology

Expression, regulation and function of intestinal drug transporters: an update

Janett Mueller et al.

BIOLOGICAL CHEMISTRY (2017)

Article Multidisciplinary Sciences

Extracellular matrix stiffness causes systematic variations in proliferation and chemosensitivity in myeloid leukemias

Jae-Won Shin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Chemistry, Analytical

A versatile lab-on-a-chip tool for modeling biological barriers

Fruzsina R. Walter et al.

SENSORS AND ACTUATORS B-CHEMICAL (2016)

Article Nanoscience & Nanotechnology

Shape Effect on Particle-Lipid Bilayer Membrane Association, Cellular Uptake, and Cytotoxicity

Thapakorn Tree-Udom et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

Review Pharmacology & Pharmacy

Regulation of ABC Transporters at the Blood-Brain Barrier

D. S. Miller

CLINICAL PHARMACOLOGY & THERAPEUTICS (2015)

Article Chemistry, Multidisciplinary

Drug and gene delivery across the blood-brain barrier with focused ultrasound

Kelsie F. Timbie et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Acoustics

LOW-INTENSITY ULTRASOUND PROMOTES CLATHRIN-DEPENDENT ENDOCYTOSIS FOR DRUG PENETRATION INTO TUMOR CELLS

Sophie Tardoski et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2015)

Review Pharmacology & Pharmacy

Mucus as a Barrier to Drug Delivery - Understanding and Mimicking the Barrier Properties

Marie Boegh et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2015)

Review Biochemical Research Methods

TEER Measurement Techniques for In Vitro Barrier Model Systems

Balaji Srinivasan et al.

Article Engineering, Biomedical

Sorafenib resistance and JNK signaling in carcinoma during extracellular matrix stiffening

Thuy V. Nguyen et al.

BIOMATERIALS (2014)

Article Engineering, Biomedical

Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness

Emi Y. Tokuda et al.

BIOMATERIALS (2014)

Article Biophysics

Quantification of Blood-Brain Barrier Solute Permeability and Brain Transport by Multiphoton Microscopy

Lingyan Shi et al.

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME (2014)

Article Gastroenterology & Hepatology

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

Michael A. Jacobetz et al.

Article Multidisciplinary Sciences

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport

Alexandre Albanese et al.

NATURE COMMUNICATIONS (2013)

Article Oncology

Ultrasonic enhancement of drug penetration in solid tumors

Chun-Yen Lai et al.

FRONTIERS IN ONCOLOGY (2013)

Review Oncology

The tumor microenvironment and strategies to improve drug distribution

Jasdeep K. Saggar et al.

FRONTIERS IN ONCOLOGY (2013)

Review Endocrinology & Metabolism

Drug transport across the blood-brain barrier

William M. Pardridge

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)

Article Endocrinology & Metabolism

A dynamic in vitro BBB model for the study of immune cell trafficking into the central nervous system

Luca Cucullo et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2011)

Article Chemistry, Multidisciplinary

Adsorption of proteins to thin-films of PDMS and its effect on the adhesion of human endothelial cells

Karin Y. Chumbimuni-Torres et al.

RSC ADVANCES (2011)

Review Physiology

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

Yulia Komarova et al.

ANNUAL REVIEW OF PHYSIOLOGY (2010)

Article Oncology

Enzymatic Depletion of Tumor Hyaluronan Induces Antitumor Responses in Preclinical Animal Models

Curtis B. Thompson et al.

MOLECULAR CANCER THERAPEUTICS (2010)

Article Biotechnology & Applied Microbiology

A Tissue-Engineered Model of the Intestinal Lacteal for Evaluating Lipid Transport by Lymphatics

J. Brandon Dixon et al.

BIOTECHNOLOGY AND BIOENGINEERING (2009)

Article Biotechnology & Applied Microbiology

Characterization of a Gastrointestinal Tract Microscale Cell Culture Analog Used to Predict Drug Toxicity

Gretchen J. Mahler et al.

BIOTECHNOLOGY AND BIOENGINEERING (2009)

Article Clinical Neurology

Characteristics of compounds that cross the blood-brain barrier

William A. Banks

BMC NEUROLOGY (2009)

Article Chemistry, Multidisciplinary

Intramuscular drug transport under mechanical loading: Resonance between tissue function and uptake

Peter I. Wu et al.

JOURNAL OF CONTROLLED RELEASE (2009)

Article Biochemistry & Molecular Biology

Effect of Extracellular Matrix Elements on the Transport of Paclitaxel through an Arterial Wall Tissue Mimic

Rachael W. Sirianni et al.

BIOMACROMOLECULES (2008)

Article Biophysics

The effect of matrix density on the regulation of 3-D capillary morphogenesis

Cyrus M. Ghajar et al.

BIOPHYSICAL JOURNAL (2008)

Review Biochemistry & Molecular Biology

The Caco-2 cell monolayer: usefulness and limitations

Huadong Sun et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)

Article Biophysics

Structural biomechanics modulate intramuscular distribution of locally delivered drugs

Peter I-Kung Wu et al.

JOURNAL OF BIOMECHANICS (2008)

Article Biochemistry & Molecular Biology

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier

Sandrine Dauchy et al.

JOURNAL OF NEUROCHEMISTRY (2008)

Review Oncology

Drug resistance and the solid tumor microenvironment

Olivier Tredan et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)

Article Biophysics

Effects of tension-compression nonlinearity on solute transport in charged hydrated fibrous tissues under dynamic unconfined compression

Chun-Yuh Huang et al.

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME (2007)

Article Cardiac & Cardiovascular Systems

Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell

Shu Chien

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

Article Biochemistry & Molecular Biology

N-glycosylation of the MUC1 mucin in epithelial cells and secretions

Simon Parry et al.

GLYCOBIOLOGY (2006)

Review Medicine, Research & Experimental

The role of shear stress in the pathogenesis of atherosclerosis

KS Cunningham et al.

LABORATORY INVESTIGATION (2005)

Article Cardiac & Cardiovascular Systems

Spatial comparison between wall shear stress measures and porcine arterial endothelial permeability

HA Himburg et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)

Review Pharmacology & Pharmacy

Transdermal drug delivery with a pressure wave

AG Doukas et al.

ADVANCED DRUG DELIVERY REVIEWS (2004)

Article Physiology

Phosphate uptake in rat skeletal muscle is reduced during isometric contractions

KA Abraham et al.

JOURNAL OF APPLIED PHYSIOLOGY (2004)

Article Biochemical Research Methods

Functional analysis of tight junctions

K Matter et al.

METHODS (2003)

Article Cell Biology

Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice

T Nitta et al.

JOURNAL OF CELL BIOLOGY (2003)

Article Physiology

Effect of force development on contraction induced glucose transport in fast twitch rat muscle

J Ihlemann et al.

ACTA PHYSIOLOGICA SCANDINAVICA (2001)

Article Physiology

Excitation-induced Ca2+ influx in rat soleus and EDL muscle:: mechanisms and effects on cellular integrity

H Gissel et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2000)