4.7 Review

Strategies targeting tumor immune and stromal microenvironment and their clinical relevance

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Intratumoral Injection of Clostridium novyi-NT Spores in Patients with Treatment-refractory Advanced Solid Tumors

Filip Janku et al.

Summary: The first-in-human study on intratumoral injection of Clostridium novyi-NT demonstrated its feasibility with manageable toxicities. The treatment induced antitumor responses and host immune reactions in patients, with most experiencing reduction or stability in injected tumor size. Further studies are warranted to explore the potential of C. novyi-NT in human therapy.

CLINICAL CANCER RESEARCH (2021)

Review Oncology

Siglec-15 as an Emerging Target for Next-generation Cancer Immunotherapy

Jingwei Sun et al.

Summary: Immunomodulatory agents targeting the PD-1/PD-L1 pathway have shown success in cancer treatment, but resistance remains a challenge. The identification of Siglec-15 as a potential immune suppressor offers a new avenue for immunotherapy, particularly in patients resistant to anti-PD-1/PD-L1 therapy.

CLINICAL CANCER RESEARCH (2021)

Review Chemistry, Multidisciplinary

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Mukaddes Izci et al.

Summary: Research has shown that despite efforts to utilize the EPR effect for enhanced delivery of nanomaterials to solid tumors, the results are still poor. Furthermore, some studies question the role of the EPR effect, suggesting that nanomaterials may enter tumors through active mechanisms rather than through endothelial gaps.

CHEMICAL REVIEWS (2021)

Article Biophysics

Legumain protease-activated tuftsin-functionalized nanoparticles for dual-targeting TAMs and cancer chemotherapy

Hui Peng et al.

Summary: In this study, a novel dual-targeting nanoparticle system for TAMs and tumor cells was developed for cancer chemotherapy. The system can be activated to promote tumor cells internalization and TAMs phagocytosis, leading to enhanced efficacy against tumor growth and TAMs depletion.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Article Chemistry, Multidisciplinary

Bifunctional Janus Particles as Multivalent Synthetic Nanoparticle Antibodies (SNAbs) for Selective Depletion of Target Cells

Jiaying Liu et al.

Summary: SNAbs are a synthetic, multivalent Janus nanotherapeutic platform that efficiently targets and depletes myeloid-derived immune-suppressor cells (MDSCs) in mouse-tumor and rat-trauma models. Injection of MDSC-targeting SNAbs in a mouse triple-negative breast cancer model successfully depletes circulating MDSCs, allowing enhanced infiltration of T cells and Natural Killer cells into tumors.

NANO LETTERS (2021)

Article Nanoscience & Nanotechnology

Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis

Mengying Hu et al.

Summary: The study reveals the key role of hepatic macrophages in mediating relaxation-induced alleviation of liver fibrosis. By developing lipid nanoparticles that target activated hepatic stellate cells and encapsulate relaxin gene and miR-30a-5p mimic, a synergistic antifibrosis effect is achieved in mouse liver fibrosis models. This approach demonstrates a proof-of-concept for devising antifibrotic strategies through the complementary application of nanotechnology and basic science.

NATURE NANOTECHNOLOGY (2021)

Review Nanoscience & Nanotechnology

Inducing immune tolerance with dendritic cell-targeting nanomedicines

Anna Cifuentes-Rius et al.

Summary: Induced tolerogenic dendritic cells offer a promising immunotherapy for autoimmune diseases, with nanomedicine presenting an alternative approach to overcome cost and customization limitations. By targeting dendritic cells with nanoparticles, this technology has the potential to address critical issues in organ transplantation and prevalent autoimmune disorders.

NATURE NANOTECHNOLOGY (2021)

Review Nanoscience & Nanotechnology

Nanomaterials for T-cell cancer immunotherapy

Ningqiang Gong et al.

Summary: T-cell-based immunotherapies show promise in treating cancer, but face challenges such as insufficient expansion of transferred T cells and inefficient trafficking into tumors. Nanomaterials offer a solution to enhance T-cell therapy by overcoming physical barriers and modulating tumor microenvironments.

NATURE NANOTECHNOLOGY (2021)

Article Biochemical Research Methods

Responsive and activable nanomedicines for remodeling the tumor microenvironment

Yinlong Zhang et al.

Summary: By regulating tumor-associated platelets and pancreatic stellate cells in the tumor microenvironment, drug delivery can be enhanced, improving the therapeutic efficacy of nanomedicines. These multifunctional nanoparticles can be used to regulate other components in the TME, achieving synergistic anti-tumor activity.

NATURE PROTOCOLS (2021)

Article Multidisciplinary Sciences

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Erez N. Baruch et al.

Summary: This study conducted a phase 1 clinical trial and found that FMT treatment in patients with anti-PD-1-refractory metastatic melanoma, along with reinduction of anti-PD-1 immunotherapy, resulted in clinical responses in some patients. This suggests that modulating the gut microbiota could be a promising approach in cancer treatment.

SCIENCE (2021)

Article Food Science & Technology

Gut microbiota targeted nanomedicine for cancer therapy: Challenges and future considerations

Muhammad Shahid Riaz Rajoka et al.

Summary: This review discusses the roles of microbiota and nanomaterials in cancer therapy, microbiota interventions via nanomaterials, microbial inspiration via nanomaterials, and challenges associated with using nanomaterials in humans and animals. The potential of nanomaterials to alter the cancer-causing microbiome/microbiota and their metabolites, as well as the cancer microenvironment, suggests novel strategies for cancer treatment. Further in vivo clinical trials are needed to determine the exact mechanisms of action in treating cancer with nanomaterials.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2021)

Article Chemistry, Multidisciplinary

Transport of nanoparticles across the endothelial cell layer

Tore Skotland et al.

Summary: Despite more than three decades of research on how nanoparticles enter and are taken up by tumor cells, there is still much to learn about their interactions and transport mechanisms across the endothelial cell layer. More studies are needed before firm conclusions can be drawn regarding the passive or energy dependent mechanisms for nanoparticle transport to solid tumors.

NANO TODAY (2021)

Article Multidisciplinary Sciences

Relaxin gene delivery modulates macrophages to resolve cancer fibrosis and synergizes with immune checkpoint blockade therapy

Xuefei Zhou et al.

Summary: The study demonstrates that targeting gene delivery-induced RLN can modulate macrophages to reduce tumor-associated fibrosis and promote infiltration of anti-tumor T cells. In addition, RLN gene delivery synergizes with PD-L1 blockade to enhance the effectiveness of immunotherapy against tumors.

SCIENCE ADVANCES (2021)

Article Engineering, Biomedical

Prolonged activation of innate immune pathways by a polyvalent STING agonist

Suxin Li et al.

Summary: A novel polyvalent STING agonist extends the activation of innate-immunity pathways through the formation of STING condensates and leads to synergistic therapeutic outcomes in vivo when combined with the STING ligand cGAMP.

NATURE BIOMEDICAL ENGINEERING (2021)

Article Chemistry, Multidisciplinary

mRNA Delivery of a Bispecific Single-Domain Antibody to Polarize Tumor-Associated Macrophages and Synergize Immunotherapy against Liver Malignancies

Ying Wang et al.

Summary: Liver malignancies are resistant to immune checkpoint inhibition therapy due to the presence of tumor-associated macrophages (TAMs) that induce immunosuppression. The study identified CCL2 and CCL5 as major chemokines responsible for TAM infiltration in liver malignancies and developed a bispecific antibody BisCCL2/5i to reverse this immunosuppressive process.

ADVANCED MATERIALS (2021)

Article Oncology

Phase I/Ib Clinical Trial of Sabatolimab, an Anti-TIM-3 Antibody, Alone and in Combination with Spartalizumab, an Anti-PD-1 Antibody, in Advanced Solid Tumors

Giuseppe Curigliano et al.

Summary: The study aimed to evaluate the safety and efficacy of Sabatolimab and spartalizumab in patients with advanced solid tumors. The results showed that the combination of Sabatolimab plus spartalizumab was well tolerated and showed signs of antitumor activity, with the recommended dose for Sabatolimab being 800 mg Q4W, with or without 400 mg spartalizumab Q4W.

CLINICAL CANCER RESEARCH (2021)

Article Medicine, Research & Experimental

Tinagl1 Gene Therapy Suppresses Growth and Remodels the Microenvironment of Triple Negative Breast Cancer

Sara N. Musetti et al.

Summary: The study found that Tinagl1 gene therapy can slow tumor growth in triple negative breast cancer without toxicity. Additionally, the use of Tinagl1 significantly increases tumor vasculature without increasing permeability or metastasis risk. Furthermore, the increase in vasculature from Tinagl1 therapy reduces the expression of Hif1a, potentially decreasing drug resistance risk.

MOLECULAR PHARMACEUTICS (2021)

Review Oncology

Therapeutic Targeting of the Tumor Microenvironment

Leire Bejarano et al.

Summary: This review provides a comprehensive analysis of the current therapies targeting the TME, combining a discussion of the underlying basic biology with clinical evaluation of different therapeutic approaches, and highlighting the challenges and future perspectives.

CANCER DISCOVERY (2021)

Article Oncology

Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor

Brendan D. Curti et al.

Summary: Combination therapy of belapectin and pembrolizumab shows promising activity in patients with metastatic melanoma and head and neck squamous cell carcinoma, with increased activation of effector memory T cells and decreased levels of monocytic myeloid-derived suppressor cells observed in responders. Additionally, increased expression of Gal-3, PD-1+CD8+ T cells, and higher serum trough levels of pembrolizumab are correlated with treatment response, indicating potential biomarkers for clinical outcomes.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Engineering, Biomedical

Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy

Jun Wang et al.

Summary: NEs-Exos system exhibits neutrophil-like chemotactic function and BBB penetration capability, efficiently suppressing tumor growth and prolonging survival time in a glioma mouse model.

BIOMATERIALS (2021)

Article Multidisciplinary Sciences

Dispersive effects and focused biodistribution of recombinant human hyaluronidase PH20: A locally acting and transiently active permeation enhancer

David W. Kang et al.

Summary: The study characterized the transient, local action of recombinant human hyaluronidase PH20 (rHuPH20) in the subcutaneous (SC) space in mice. Results demonstrated enzymatic activity near the injection site without systemic exposure, and showed that delivery of rHuPH20 at one site did not impact dye dispersion at a distal skin site.

PLOS ONE (2021)

Article Engineering, Biomedical

Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel

Kai Han et al.

Summary: Modulating the gut microbiome with orally administered gel can induce systemic antitumour immunity and enhance the activity of immune checkpoint inhibitors in murine tumour models. This method shows promise for treating pathologies associated with dysregulated gut microbiome.

NATURE BIOMEDICAL ENGINEERING (2021)

Article Hematology

PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia

Jessica Li et al.

Summary: The study showed that PVRIG blockade enhanced NK-cell killing of AML cell lines and increased NK-cell activation and degranulation in patient primary AML blasts. However, NK-cell PVRIG expression levels were not increased in AML patient bone marrow. The findings suggest that anti-PVRIG blocking antibody can target the PVRIG-PVRL2 immune checkpoint axis for NK-mediated immunotherapy of PVRL2(+) AML.

HAEMATOLOGICA (2021)

Article Oncology

FDA Approval Summary: Alpelisib Plus Fulvestrant for Patients with HR-positive, HER2-negative, PIK3CA-mutated, Advanced or Metastatic Breast Cancer

Preeti Narayan et al.

Summary: The FDA granted regular approval to alpelisib in combination with fulvestrant for hormone receptor-positive, HER2-negative, PIK3CA-mutated advanced or metastatic breast cancer patients. Results from the SOLAR-1 study showed a significant improvement in PFS with the combination therapy compared to the control group.

CLINICAL CANCER RESEARCH (2021)

Article Immunology

TAM receptors attenuate murine NK-cell responses via E3 ubiquitin ligase Cbl-b

Leilani M. Chirino et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2020)

Review Pharmacology & Pharmacy

Tumor microenvironment responsive drug delivery systems

Qunye He et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Article Chemistry, Physical

The entry of nanoparticles into solid tumours

Shrey Sindhwani et al.

NATURE MATERIALS (2020)

Article Multidisciplinary Sciences

Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties

Yuya Terashima et al.

NATURE COMMUNICATIONS (2020)

Article Chemistry, Multidisciplinary

Size-Tunable Strategies for a Tumor Targeted Drug Delivery System

Wenqi Yu et al.

ACS CENTRAL SCIENCE (2020)

Article Chemistry, Multidisciplinary

The Influence of Nanoparticle Shape on Protein Corona Formation

Rahul Madathiparambil Visalakshan et al.

Review Medicine, Research & Experimental

CXCL12/CXCR4 axis in the microenvironment of solid tumors: A critical mediator of metastasis

Keywan Mortezaee

LIFE SCIENCES (2020)

Editorial Material Chemistry, Physical

Active transcytosis and new opportunities for cancer nanomedicine

Subehndu Pandit et al.

NATURE MATERIALS (2020)

Review Biochemical Research Methods

The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy

Valentina Francia et al.

BIOCONJUGATE CHEMISTRY (2020)

Article Multidisciplinary Sciences

Trispecific natural killer cell nanoengagers for targeted chemoimmunotherapy

Kin Man Au et al.

SCIENCE ADVANCES (2020)

Review Chemistry, Multidisciplinary

Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics

Fei Gong et al.

NANO TODAY (2020)

Article Multidisciplinary Sciences

Specific targeting of ovarian tumor-associated macrophages by large, anionic nanoparticles

Tom Haber et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

Luis Felipe Campesato et al.

NATURE COMMUNICATIONS (2020)

Review Biology

A perspective on HPK1 as a novel immuno-oncology drug target

Sansana Sawasdikosol et al.

Article Oncology

Cancer Immunotherapy and the Nectin Family

Robert J. Johnston et al.

Annual Review of Cancer Biology-Series (2020)

Article Oncology

A framework for advancing our understanding of cancer-associated fibroblasts

Erik Sahai et al.

NATURE REVIEWS CANCER (2020)

Review Immunology

TIM3 comes of age as an inhibitory receptor

Yochai Wolf et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Immunology

Targeting natural killer cells in solid tumors

Guillaume Habif et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2019)

Article Multidisciplinary Sciences

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Takeshi Tanoue et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy

Jun Wang et al.

NATURE MEDICINE (2019)

Article Cell Biology

Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs

Susannah L. Hewitt et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Review Immunology

Targeting Tumor-Associated Macrophages in Cancer

Paulina Pathria et al.

TRENDS IN IMMUNOLOGY (2019)

Review Oncology

Cancer-associated fibroblasts-heroes or villains?

Krystyna A. Gieniec et al.

BRITISH JOURNAL OF CANCER (2019)

Article Multidisciplinary Sciences

Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy

Mengying Hu et al.

NATURE COMMUNICATIONS (2019)

Review Immunology

Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function

Selena Vigano et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Chemistry, Multidisciplinary

Smart Nanotherapeutic Targeting of Tumor Vasculature

Zifu Li et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Review Oncology

Treg-mediated acquired resistance to immune checkpoint inhibitors

Reem Saleh et al.

CANCER LETTERS (2019)

Review Immunology

Macrophage Rewiring by Nutrient Associated PI3K Dependent Pathways

Omar Sharif et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Pharmacology & Pharmacy

Physical and chemical profiles of nanoparticles for lymphatic targeting

Xiyu Ke et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

Review Biochemistry & Molecular Biology

Targeting Tumor Endothelial Cells with Nanoparticles

Yu Sakurai et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Nanoscience & Nanotechnology

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

Qian Chen et al.

NATURE NANOTECHNOLOGY (2019)

Review Nanoscience & Nanotechnology

Nanotechnology intervention of the microbiome for cancer therapy

Wantong Song et al.

NATURE NANOTECHNOLOGY (2019)

Article Oncology

PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function

Sarah Whelan et al.

CANCER IMMUNOLOGY RESEARCH (2019)

Article Chemistry, Multidisciplinary

Dual-Stimuli-Responsive Gut Microbiota-Targeting Berberine-CS/PT-NPs Improved Metabolic Status in Obese Hamsters

Hui-Hui Guo et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

Review Oncology

New emerging targets in cancer immunotherapy: the role of TIM3

Alex Friedlaender et al.

ESMO OPEN (2019)

Review Medicine, Research & Experimental

CD36 tango in cancer: signaling pathways and functions

Jingchun Wang et al.

THERANOSTICS (2019)

Article Oncology

Scavenger Receptor Type B1 and Lipoprotein Nanoparticle Inhibit Myeloid-Derived Suppressor Cells

Michael P. Plebanek et al.

MOLECULAR CANCER THERAPEUTICS (2018)

Review Chemistry, Multidisciplinary

Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities

Lisa Belfiore et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Article Chemistry, Multidisciplinary

Regulatory T cell-targeted hybrid nanoparticles combined with immuno-checkpoint blockage for cancer immunotherapy

Wenquan Ou et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Article Biotechnology & Applied Microbiology

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

Li Tang et al.

NATURE BIOTECHNOLOGY (2018)

Review Medicine, General & Internal

Immune-Related Adverse Events Associated with Immune Checkpoint Blockade

Michael A. Postow et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade

Victoria Klepsch et al.

NATURE COMMUNICATIONS (2018)

Review Nanoscience & Nanotechnology

Bioresponsive materials

Yue Lu et al.

NATURE REVIEWS MATERIALS (2017)

Article Chemistry, Multidisciplinary

Targeting tumor associated macrophages (TAMs) via nanocarriers

Yuvraj Singh et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Review Chemistry, Multidisciplinary

Revisiting structure-property relationship of pH-responsive polymers for drug delivery applications

Salime Bazban-Shotorbani et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Article Chemistry, Multidisciplinary

A polymer nanoparticle with engineered affinity for a vascular endothelial growth factor (VEGF165)

Hiroyuki Koide et al.

NATURE CHEMISTRY (2017)

Article Nanoscience & Nanotechnology

Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

Jingwei Xue et al.

NATURE NANOTECHNOLOGY (2017)

Review Cell Biology

Metabolic Interactions in the Tumor Microenvironment

Costas A. Lyssiotis et al.

TRENDS IN CELL BIOLOGY (2017)

Review Immunology

TIGIT: A Key Inhibitor of the Cancer Immunity Cycle

Nicholas A. Manieri et al.

TRENDS IN IMMUNOLOGY (2017)

Article Virology

The role of CD27 in anti-viral T-cell immunity

Emma J. Grant et al.

CURRENT OPINION IN VIROLOGY (2017)

Article Chemistry, Multidisciplinary

Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation

Tianjiao Ji et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Biochemistry & Molecular Biology

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

Roger Geiger et al.

Article Nanoscience & Nanotechnology

A tenascin C targeted nanoliposome with navitoclax for specifically eradicating of cancer-associated fibroblasts

Binlong Chen et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

Article Multidisciplinary Sciences

PI3Kγ is a molecular switch that controls immune suppression

Megan M. Kaneda et al.

NATURE (2016)

Review Immunology

The development and maintenance of resident macrophages

Elisa Gomez Perdiguero et al.

NATURE IMMUNOLOGY (2016)

Review Cell Biology

Mechanisms and regulation of endothelial VEGF receptor signalling

Michael Simons et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Cell Biology

Local and transient gene expression primes the liver to resist cancer metastasis

Tyler J. Goodwin et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Review Immunology

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

Vinit Kumar et al.

TRENDS IN IMMUNOLOGY (2016)

Review Multidisciplinary Sciences

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Vincenzo Bronte et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

Revised Estimates for the Number of Human and Bacteria Cells in the Body

Ron Sender et al.

PLOS BIOLOGY (2016)

Article Nanoscience & Nanotechnology

Analysis of nanoparticle delivery to tumours

Stefan Wilhelm et al.

NATURE REVIEWS MATERIALS (2016)

Review Oncology

Targeting tumor vasculature: expanding the potential of DNA cancer vaccines

Stefano Ugel et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2015)

Article Biochemistry & Molecular Biology

Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect

David J. DiLillo et al.

Review Biotechnology & Applied Microbiology

Therapeutic approaches to enhance natural killer cell cytotoxicity against cancer: the force awakens

Richard W. Childs et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Review Oncology

Modulation of immune cell functions by the E3 ligase Cbl-b

Christina Lutz-Nicoladoni et al.

FRONTIERS IN ONCOLOGY (2015)

Review Oncology

S100 proteins in cancer

Anne R. Bresnick et al.

NATURE REVIEWS CANCER (2015)

Article Multidisciplinary Sciences

The cellular and molecular origin of tumor-associated macrophages

Ruth A. Franklin et al.

SCIENCE (2014)

Review Oncology

Local targets for immune therapy to cancer: Tumor draining lymph nodes and tumor microenvironment

Marieke F. Fransen et al.

INTERNATIONAL JOURNAL OF CANCER (2013)

Article Biotechnology & Applied Microbiology

Liposomes surface conjugated with human hemoglobin target delivery to macrophages

Ning Zhang et al.

BIOTECHNOLOGY AND BIOENGINEERING (2012)

Article Medicine, Research & Experimental

TNF signaling drives myeloid-derived suppressor cell accumulation

Xueqiang Zhao et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Review Chemistry, Multidisciplinary

Targeting tumor antigens to dendritic cells using particulate carriers

Medha D. Joshi et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Article Chemistry, Multidisciplinary

Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor

Jun Li et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Article Biochemistry & Molecular Biology

Selection and characterization of tenascin C targeting peptide

Mee Young Kim et al.

MOLECULES AND CELLS (2012)

Article Multidisciplinary Sciences

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

Benjamin Diop-Frimpong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Chemistry, Multidisciplinary

Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery

Jun Li et al.

JOURNAL OF CONTROLLED RELEASE (2010)

Article Biochemistry & Molecular Biology

Nanoparticles evading the reticuloendothelial system: Role of the supported bilayer

Shyh-Dar Li et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2009)

Article Pharmacology & Pharmacy

A review and update of the current status of the vasculature-disabling agent combretastatin-A4 phosphate (CA4P)

Dietmar W. Siemann et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)

Article Engineering, Biomedical

Control of Growth Factor Networks by Heparan Sulfate Proteoglycans

Kimberly Forsten-Williams et al.

ANNALS OF BIOMEDICAL ENGINEERING (2008)

Review Cell Biology

Connective tissue growth factor (CTGF) and cancer progression

Chia-Yu Chu et al.

JOURNAL OF BIOMEDICAL SCIENCE (2008)

Article Multidisciplinary Sciences

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Hiroki Ishikawa et al.

NATURE (2008)

Review Biochemistry & Molecular Biology

Novel antibodies as anticancer agents

I. Zafir-Lavie et al.

ONCOGENE (2007)

Article Multidisciplinary Sciences

T cell surface redox levels determine T cell reactivity and arthritis susceptibility

Kyra A. Gelderman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Regulation of T cell receptor CD3 chain expression by L-arginine

PC Rodriguez et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)