4.1 Article

Central nervous system monoamine metabolite response to alcohol exposure is associated with future alcohol intake in a nonhuman primate model (Macaca mulatta)

期刊

ADDICTION BIOLOGY
卷 27, 期 3, 页码 -

出版社

WILEY
DOI: 10.1111/adb.13142

关键词

alcohol; dopamine; monoamines; norepinephrine; rhesus monkeys; serotonin

资金

  1. Brigham Young University
  2. Eunice Kennedy Shriver National Institute of Child Health and Human Development
  3. National Institute on Alcohol Abuse and Alcoholism

向作者/读者索取更多资源

This study investigates the relationship between monoamine activity and alcohol intake using a nonhuman primate model. The results show that there is a positive correlation between monoamine metabolite concentrations and alcohol intake. Low serotonin and dopamine metabolite concentrations, as well as a smaller change in these metabolites, are associated with higher alcohol intake. On the other hand, low baseline norepinephrine metabolite concentrations and a greater change in these metabolites are also associated with higher alcohol intake.
It is widely held that the central monoamine neurotransmitters modulate alcohol intake. Few studies, however, directly assess the relationship between baseline and alcohol-induced monoamine turnover, as well as the change from baseline, as predictors of alcohol intake. Using a nonhuman primate model, this study investigates baseline, alcohol-induced and alcohol-induced change in monoamine activity and their relationship with alcohol intake. Alcohol-naive, adolescent rhesus macaques (Macaca mulatta, N = 114) were administered a standardized intravenous bolus of alcohol solution (16.8%, v/v) on two occasions, approximately 1 month apart. One month prior to and 1 h following each alcohol infusion, cisternal cerebrospinal fluid (CSF) was obtained and assayed for monoamine metabolite concentrations. Approximately 6-7 months later, subjects were allowed unfettered access to an aspartame-sweetened alcohol solution (8.4%, v/v) for 1 h/day, 5 days/week, over 5-7 weeks. Results showed strong positive correlations between baseline and post-infusion CSF monoamine metabolite concentrations, indicating a trait-like response. Low baseline and post-infusion serotonin and dopamine metabolite concentrations and a smaller change in serotonin and dopamine metabolites from one infusion to the next were associated with higher alcohol intake. Low baseline and post-infusion norepinephrine metabolite concentrations predicted high alcohol intake, but unlike the other monoamines, a greater change in norepinephrine metabolite concentrations from one infusion to the next was associated with higher alcohol intake. These findings suggest that individual differences in naturally occurring and alcohol-induced monoamine activity, as well as the change between exposures, are important modulators of initial alcohol consumption and may play a role in the risk for excessive alcohol intake.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.1
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据