期刊
ACTA TROPICA
卷 228, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.actatropica.2022.106325
关键词
Artemisia aucheri; Leishmaniasis; Silver nanoparticles; Wound healing
资金
- Birjand University of Medical Sciences [5067]
This study synthesized silver nanoparticles from Artemisia aucheri leaf extract and examined their effects on leishmaniasis and antibacterial activity. The results showed that the ointment containing quercetin/artemisia-capped silver nanoparticles could promote wound healing and reduce inflammatory responses.
Leishmaniasis is a major health issue that affects people all over the world, producing considerable morbidity and mortality in Asia, Africa, and the Americas, and existing treatments have significant side effects. Nowadays, the development of nanoscale materials such as biogenic silver nanoparticles has attracted much medical attraction. In this study, AgNPs were synthesized from leaf extract of Artemisia aucheri. Biosynthesized AgNPs were analyzed by UV-visible spectroscopy, dynamic light scattering and zeta potential, fourier transform infrared spectroscopy and field emission scanning electron microscopy. Biosynthesized AgNPs were examined for anti-leishmanial and antibacterial activity. The in vivo study was conducted by treating the L. major infected BALB/c mice with quercetin/ artemisia-capped silver nanoparticles ointment topically for 21 consecutive days. The in vitro and in vivo results showed that the ointment containig quercetin/artemisia-capped silver nanoparticles have the potential to decrease inflammatory responses and enhance wound healing with granulation tissue formation compared to the untreated group. Therefore, biogenic nanoparticles are safe, eco-friendly, and easy to synthesize and could be considered as an alternative regimen for treatment of L. major.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据