4.5 Review

Multivitamin use and risk of preeclampsia: A systematic review and meta-analysis

期刊

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
卷 101, 期 10, 页码 1038-1047

出版社

WILEY
DOI: 10.1111/aogs.14356

关键词

eclampsia; HELLP; micronutrients; multivitamin; preeclampsia; pregnancy; pregnant women

向作者/读者索取更多资源

This systematic review and meta-analysis examined the association between multivitamin use and the risk of preeclampsia. The results showed very weak evidence suggesting that multivitamin use might reduce the risk of preeclampsia. However, due to limited and low-quality studies, further large-scale randomized controlled trials are needed to confirm these findings. Therefore, no final conclusions can be drawn regarding the preventive effect of multivitamin use in relation to preeclampsia based on the results of this review.
Introduction Preeclampsia is associated with adverse maternal and neonatal outcomes. It is unclear whether multivitamin use reduces the risk of preeclampsia. This systematic review and meta-analysis aimed to evaluate the association between multivitamin use and the risk of preeclampsia. Material and methods We searched PubMed, Embase and the Cochrane Library from database inception to July 2021. Randomized controlled trials (RCTs), case-control and cohort studies assessing the association between multivitamin use and risk of preeclampsia were eligible. Studies of treatment with a single micronutrient were excluded. Relative risks and 95% confidence intervals (95% CI) were calculated using random-effects models. RoB2, the Newcastle Ottawa Scale and GRADE were used to assess risk of bias and quality of evidence. The protocol was registered in PROSPERO (no. CRD42021214153). Results Six studies were included (33 356 women). Only two RCTs were found, both showing a significantly decreased risk of preeclampsia in multivitamin users. These studies were not compatible for meta-analysis due to clinical heterogeneity. A meta-analysis of observational studies using a random-effects model showed an unchanged risk of preeclampsia following multivitamin use (relative risk 0.85, 95% CI 0.69-1.03). The quality of evidence according to GRADE was very low. Conclusions Very weak evidence suggests that multivitamin use might reduce the risk of preeclampsia; however, more research is needed. Large RCTs should be prioritized. The results of this review do not allow any final conclusions to be drawn regarding a preventive effect of multivitamin use in relation to preeclampsia.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据