期刊
ACTA BIOMATERIALIA
卷 146, 期 -, 页码 357-369出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2022.05.014
关键词
Golgi apparatus; Prodrug; Immunosuppression; Photodynamic therapy; Cancer
资金
- National Natural Science Foundation of China [81872804, 81690261]
- Sichuan major science and technology project on biotechnology and medicine [2018SZDZX0018]
- Central Government Funds of Guiding Local Scientific and Technological Development for Sichuan Province [2021ZYD0070]
This study presents a promising approach for photodynamic immunotherapy of advanced cancers by using chondroitin sulfate-based prodrug nanoparticles to co-deliver a photosensitizer and retinoic acid. This approach can reduce the immunosuppression caused by photodynamic therapy and promote the maturation of dendritic cells. The strategy showed excellent antitumor efficacy in a mouse model.
Photodynamic therapy (PDT) is an emerging therapeutic approach that can inhibit tumor growth by destroying local tumors and activating systemic antitumor immune responses. However, PDT can be ineffective because of photosensitizer aggregation, tumor-induced dendritic cells (DC S ) dysfunction and PDT-mediated immunosuppression. Therefore, we designed chondroitin sulfate-based prodrug nanoparticles for the co-delivery of the photosensitizer chlorin e6 (Ce6) and retinoic acid (RA), which can reduce PDT-mediated immunosuppression by disrupting the Golgi apparatus and blocking the production of immunosuppressive cytokines. Moreover, CpG oligodeoxynucleotide was combined as immunoadjuvant to promote the maturation of DCs. As expected, the strategy of Golgi apparatus targeting immunotherapy combined PDT was confirmed to relieve PDT-induced immunosuppression, showed excellent PDT antitumor efficacy in B16F10-subcutaneous bearing mice model. Thus, our finding offers a promising approach for photodynamic immunotherapy of advanced cancers.
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