4.8 Article

Facile calcium ion-regulated grafting of dense and highly stretched hyaluronan for selective mediation of cancer cells rolling under high-speed flow

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Article Polymer Science

Strong Reduction of the Chain Rigidity of Hyaluronan by Selective Binding of Ca2+ Ions

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Summary: The study reveals that calcium ions specifically bind to hyaluronan, weakening its intramolecular hydrogen bond network and increasing the flexibility of the polymer chain. Furthermore, the binding of calcium saturates at a certain fraction, reducing the probability of subsequent binding at neighboring sites.

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