Epithelial folding of alveolar cells derived from human induced pluripotent stem cells on artificial basement membrane

Article Engineering, Biomedical

Nanocasting of fibrous morphology on a substrate for long-term propagation of human induced pluripotent stem cells

Sisi Li et al.

Summary: A casting method is developed to replicate the nanofibrous morphology onto a thin layer of PDMS, which proves to be a flexible and cost-effective approach for propagating hiPSCs.

BIOMEDICAL MATERIALS (2022)

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Article Engineering, Biomedical

Modulation of designer biomimetic matrices for optimized differentiated intestinal epithelial cultures

Wang Xi et al.

Summary: This study developed hydrogel scaffolds with different elasticities and investigated their influence on the expansion, organization, and differentiation of intestinal epithelial cells. The results showed that cells on soft substrates exhibited improved characteristics resembling in vivo intestinal tissue, which is of significant importance for the design of biomaterials for ex vivo intestinal models.

BIOMATERIALS (2022)

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Article Biochemistry & Molecular Biology

Reconstituted basement membrane enables airway epithelium modeling and nanoparticle toxicity testing

Elrade Rofaani et al.

Summary: This study successfully generated airway epithelium using artificial basement membrane (ABM) and human-induced pluripotent stem cells (hiPSCs). The generated pseudostratified airway epithelium consists of multiple cell types and demonstrates advantages over other methods.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Nanoscience & Nanotechnology

Generation of Interconnected Neural Clusters in Multiscale Scaffolds from Human-Induced Pluripotent Stem Cells

Boxin Huang et al.

Summary: The research focuses on a method to generate interconnected neural clusters in a multiscale scaffold, leading to the formation of two types of neural clusters and indicating the complexity of neural-scaffold interaction and the variability of neural organization.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Engineering, Biomedical

Organoid engineering with microfluidics and biomaterials for liver, lung disease, and cancer modeling

Su Kyeom Kim et al.

Summary: Advancements in organoid technology have allowed for better replication of in vivo organ environments, overcoming limitations of existing disease models. Integration of engineering approaches such as microfluidics and biomaterials is necessary for more precise disease modeling. Combined with organoids, these engineered disease models provide a powerful platform for personalized medicine research.

ACTA BIOMATERIALIA (2021)

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Review Biochemistry & Molecular Biology

SARS-CoV-2 Infection and Disease Modelling Using Stem Cell Technology and Organoids

Marta Trevisan et al.

Summary: This Review briefly describes the virology and pathogenesis of SARS-CoV-2, emphasizing how stem cell technology and organoids can help understand the cell tropisms of SARS-CoV-2 and its disease mechanisms in the human host. Studies using these technologies showed that lung epithelial cells, gastrointestinal cells, heart cells, and choroid plexus epithelial cells are key targets of SARS-CoV-2, leading to cell damage and inflammation. Neurological symptoms and vascular damage are suggested to be indirect effects of systemic inflammatory and immunological responses to SARS-CoV-2 infection, as endothelial cells and neurons are less susceptible to viral infection.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

To form and function: on the role of basement membrane mechanics in tissue development, homeostasis and disease

Nargess Khalilgharibi et al.

Summary: The basement membrane plays a crucial role in tissue development and diseases, with its complex mechanical properties changing through different molecular mechanisms, thereby affecting tissue form and function. Investigating the mechanical properties of the basement membrane is important for disease diagnosis and treatment, as well as the development of better in silico and in vitro models, which can also reduce the use of animals in research.

OPEN BIOLOGY (2021)

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Review Genetics & Heredity

Angiotensin-Converting Enzyme 2 (ACE2) as a Potential Diagnostic and Prognostic Biomarker for Chronic Inflammatory Lung Diseases

Dejan Marcetic et al.

Summary: Chronic inflammatory lung diseases are characterized by uncontrolled immune response in the airways, and the lack of specific diagnostic and therapeutic biomarkers poses a major challenge for pulmonologists. Approved therapeutic approaches focus on achieving disease remission, while the protective role of ACE2 in the lungs and its exact pathophysiological mechanism of action remain unclear.

GENES (2021)

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Review Biotechnology & Applied Microbiology

A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems

Luana A. Osorio et al.

Summary: Organ-on-a-Chip (OOAC) systems are engineered microfluidic systems that mimic the physiological environment of specific organs and have the potential to replace animal models. The success of cell cultures within these systems depends on the choice of scaffold, highlighting the critical role of scaffolds in OOAC research.

BIOENGINEERING-BASEL (2021)

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Article Chemistry, Physical

Actomyosin controls planarity and folding of epithelia in response to compression

Tom P. J. Wyatt et al.

NATURE MATERIALS (2020)

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Article Cell & Tissue Engineering

Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors

Killian Hurley et al.

CELL STEM CELL (2020)

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Review Nanoscience & Nanotechnology

The stiffness of living tissues and its implications for tissue engineering

Carlos F. Guimaraes et al.

NATURE REVIEWS MATERIALS (2020)

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Article Biotechnology & Applied Microbiology

Alveolar mimics with periodic strain and its effect on the cell layer formation

Milad Radiom et al.

BIOTECHNOLOGY AND BIOENGINEERING (2020)

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Article Engineering, Electrical & Electronic

Fabrication of ultrathin artificial basement membrane for epithelial cell culture

Elrade Rofaani et al.

MICROELECTRONIC ENGINEERING (2020)

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Article Multidisciplinary Sciences

Human pluripotent stem cell-derived alveolar epithelial cells are alternatives for in vitro pulmotoxicity assessment

Hye-Ryeon Heo et al.

SCIENTIFIC REPORTS (2019)

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Article Engineering, Biomedical

Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier

Ana Costa et al.

ACTA BIOMATERIALIA (2019)

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Review Biochemistry & Molecular Biology

Mechanochemical Feedback Loops in Development and Disease

Edouard Hannezo et al.

CELL (2019)

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Article Cell Biology

Planar Differential Growth Rates Initiate Precise Fold Positions in Complex Epithelia

Melda Tozluoglu et al.

DEVELOPMENTAL CELL (2019)

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Review Nanoscience & Nanotechnology

Material approaches to active tissue mechanics

Wang Xi et al.

NATURE REVIEWS MATERIALS (2019)

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Review Biophysics

Biophysics in oviduct: Planar cell polarity, cilia, epithelial fold and tube morphogenesis, egg dynamics

Hiroshi Koyama et al.

BIOPHYSICS AND PHYSICOBIOLOGY (2019)

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Article Biophysics

Cell-Cell Adhesion and Cortical Actin Bending Govern Cell Elongation on Negatively Curved Substrates

Ai Kia Yip et al.

BIOPHYSICAL JOURNAL (2018)

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Article Cell Biology

Morphogenesis and Compartmentalization of the Intestinal Crypt

Kaelyn D. Sumigray et al.

DEVELOPMENTAL CELL (2018)

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Article Multidisciplinary Sciences

Active superelasticity in three-dimensional epithelia of controlled shape

Ernest Latorre et al.

NATURE (2018)

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Article Engineering, Electrical & Electronic

Patch method for culture of primary hippocampal neurons

Yadong Tang et al.

MICROELECTRONIC ENGINEERING (2017)

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Article Multidisciplinary Sciences

Topological defects in epithelia govern cell death and extrusion

Thuan Beng Saw et al.

NATURE (2017)

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Article Cell Biology

A three-dimensional model of human lung development and disease from pluripotent stem cells

Ya-Wen Chen et al.

NATURE CELL BIOLOGY (2017)

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Review Biology

Cellular systems for epithelial invagination

Esther J. Pearl et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2017)

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Article Pathology

Stem Cells in Lung Injury and Repair

Felicia Chen et al.

AMERICAN JOURNAL OF PATHOLOGY (2016)

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Article Biophysics

Quantitative Morphology of Epithelial Folds

Nick Storgel et al.

BIOPHYSICAL JOURNAL (2016)

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Article Chemistry, Multidisciplinary

Induction and differentiation of human induced pluripotent stem cells into functional cardiomyocytes on a compartmented monolayer of gelatin nanofibers

Yadong Tang et al.

NANOSCALE (2016)

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Article Physics, Multidisciplinary

Large deflection of clamped circular plate and accuracy of its approximate analytical solutions

Yin Zhang

SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY (2016)

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Article Biochemistry & Molecular Biology

Alveolar Development and Disease

Jeffrey A. Whitsett et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2015)

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Article Biochemical Research Methods

A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

Andreas O. Stucki et al.

LAB ON A CHIP (2015)

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Article Engineering, Biomedical

Nanofibrous gelatin substrates for long-term expansion of human pluripotent stem cells

Li Liu et al.

BIOMATERIALS (2014)

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Article Biochemistry & Molecular Biology

Cytoskeletal Tension Inhibits Hippo Signaling through an Ajuba-Warts Complex

Cordelia Rauskolb et al.

CELL (2014)

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Article Biotechnology & Applied Microbiology

Efficient generation of lung and airway epithelial cells from human pluripotent stem cells

Sarah X. L. Huang et al.

NATURE BIOTECHNOLOGY (2014)

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Article Multidisciplinary Sciences

Characterizing the mechanics of cultured cell monolayers

Andrew R. Harris et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Physiology

Cyclic deformation-induced injury and differentiation of rat alveolar epithelial type II cells

Huan Ye et al.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2012)

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Article Physics, Multidisciplinary

Instabilities of Monolayered Epithelia: Shape and Structure of Villi and Crypts

E. Hannezo et al.

PHYSICAL REVIEW LETTERS (2011)

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Review Pathology

Epithelial Barriers in Homeostasis and Disease

Amanda M. Marchiando et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

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Article Multidisciplinary Sciences

Reconstituting Organ-Level Lung Functions on a Chip

Dongeun Huh et al.

SCIENCE (2010)

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Review Biochemistry & Molecular Biology

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

Andrea Hartsock et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)

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Article Cell Biology

Cell adhesion receptors in mechanotransduction

Martin A. Schwartz et al.

CURRENT OPINION IN CELL BIOLOGY (2008)

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Article Multidisciplinary Sciences

Emergent patterns of growth controlled by multicellular form and mechanics

CM Nelson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Medicine, Research & Experimental

Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells:: development of an alveolo-capillary barrier in vitro

MI Hermanns et al.

LABORATORY INVESTIGATION (2004)

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Epithelial folding of alveolar cells derived from human induced pluripotent stem cells on artificial basement membrane

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