Boronic Acid-Decorated Multivariate Photosensitive Metal-Organic Frameworks for Combating Multi-Drug-Resistant Bacteria

Metal-organic frameworks (MOFs) are promising photosensitized materials that have displayed great advantages in antibacterial application. However, their bactericidal activity is still limited by the ultrashort diffusion distance of biocidal reactive oxygen species (ROS). Herein, we integrate the bacterial-binding boronic acid ligand and photosensitized porphyrin into one single MOF, synergistically boosting antibiotic capability. The introduction of the boronic acid group with a closed physical gap makes multivariate MOFs more powerful for eradicating multi-drug-resistant (MDR) bacteria. The MOFs that are decorated with boronic acid possess antibacterial efficiencies (10-20 times) higher than those without the targeting ligand. Moreover, the MOFs exhibit excellent biocompatibility. They significantly decrease the inflammatory responses and accelerate the healing of chronic wounds infected with MDR bacteria (nearly 2 times faster). This work provides a strategy to develop multivariate MOFs that target bacteria, which will further inspire specific bacterial-binding therapy in the future.

Automated summary

Researchers have integrated bacterial-binding boronic acid ligands and photosensitized porphyrins into a single metal-organic framework (MOF), enhancing its antibacterial capabilities. The introduction of boronic acid groups significantly improves the ability to eradicate multi-drug-resistant bacteria and the MOFs also exhibit excellent biocompatibility. This study provides a new strategy for targeted bacterial therapy.