Visible-Light-Mediated Nano-biomineralization of Customizable Tough Hydrogels for Biomimetic Tissue Engineering

Biomineralized tough hydrogels (BTHs) have advanced applications in the fields of soft bioelectronics and biomimetic tissue engineering. But the development of rapid and general photomineralization strategies for one-step fabrication of customizable BTHs is still a challenging task. Here we report a straightforward, low-cost visible-lightmediated nano-biomineralization (VLMNB) strategy via a rational design of a phosphate source and efficient ruthenium photochemistry. Multinetwork tough hydrogels are simultaneously constructed under the same condition. Therefore, BTHs are rapidly prepared in a short time as low as similar to 60 s under visible light irradiation. The in situ formation of calcium phosphate particles can improve BTHs' mechanical and biological properties and reduce the friction coefficient with bones. Furthermore, fast biomineralization and solidification processes in these BTHs benefit their injectable and highly flexible customizable design, showing applications of promoting customizable skin repair and bone regeneration.

Automated summary

A straightforward and low-cost visible-lightmediated nano-biomineralization strategy was developed for rapid preparation of Biomineralized tough hydrogels (BTHs). This strategy allows for the improvement of mechanical and biological properties of BTHs, making them suitable for applications such as skin repair and bone regeneration.