期刊
ACS APPLIED MATERIALS & INTERFACES
卷 14, 期 16, 页码 18233-18247出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c04274
关键词
nanoparticles; gadolinium fluoride; luminescence; MRI; pancreatic islets; beta-cells
资金
- Czech Science Foundation (CSF) [21-04420S]
- Operational Programme Research, Development and Education - European Structural and Investment funds
- Czech Ministry of Education, Youth and Sports [CZ.02.1.01/0.0/0.0/16_019/0000760]
- National Infrastructure for Biological and Medical Imaging at the BioImaging facility at the Institute of Physiology [LM2018129]
- CSF [20-07313S]
Novel Yb, Tb, Nd-doped GdF3 and NaGdF4 nanoparticles were synthesized and their properties were controlled by varying the stabilizer concentration and fluoride source in the reaction. These nanoparticles exhibited excellent optical and magnetic properties, and achieved superior contrast in in vivo MR imaging of pancreatic islets.
Novel Yb,Tb,Nd-doped GdF3 and NaGdF4 nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) in the presence of the poly(4-styrenesullonic acid-co-maleic anhydride) stabilizer. The particle size and morphology, crystal structure, and phase change were controlled by adjusting the PSSMA concentration and source of fluoride anions in the reaction. Doping of Yb3+, Tb3+, and Nd3+ ions in the NaGdF4 host nanoparticles induced luminescence under ultraviolet and nearinfrared excitation and high relaxivity in magnetic resonance (MR) imaging (MRI). In vitro toxicity of the nanoparticles and their cellular uptake efficiency were determined in model rat pancreatic beta-cells (INS-IE). As the NaGdF4 :Yb,Tb,Nd@PSSMA-EG nanoparticles were non-toxic and possessed good luminescence and magnetic properties, they were applicable for in vitro optical and MRI of isolated pancreatic islets in phantoms. The superior contrast was achieved for in vivo T-2*-weighted MR images of the islets transplanted under the kidney capsule to mice in preclinical trials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据