期刊
ACS APPLIED MATERIALS & INTERFACES
卷 14, 期 12, 页码 14087-14096出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c00448
关键词
self-assembly; photothermal therapy; alkyl radicals; biomaterial; solid tumors
资金
- National Nature Science Foundation of China [22177065, 21977065, 21807067]
- SanJin Scholars Support Plan under Special Funding [2017-06]
- Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [2019L0022]
- Fund for Shanxi
- Natural Science Foundation of Shanxi Province [202103021224340]
- Program for Introducing Overseas High-level Talents of Shanxi
Incomplete local treatment is the main cause of difficult-to-cure solid tumors. In this work, a self-assembled biomaterial triggered by near-infrared light is developed, which effectively eliminates local lesions of solid tumors and improves the cure rate.
Incomplete local treatment of solid tumors is the main cause of tumor difficult to cure, and easily leads to tumor metastasis and recurrence. The dense external matrix and hypoxic microenvironment of solid tumors severely restrict the therapy efficacy of local tumors. Enhancing the infiltration ability of agents to tumor tissues and adapting the therapy mode favored to hypoxic microenvironments are beneficial to improve the cure rate of tumors. In this work, we designed and developed a self-assembled biomaterial with a cascade effect triggered by near-infrared light. The self-assembly was combined of biotin, phase change material (PNIPAM), photochemical agent (ATT-2), and alkyl radical generator (AIPH). In the assembly, biotin acted as a targeted group. ATT-2 was used to provide heat to synergistically induce the phase change and decompose alkyl radicals. The superficial and deep tumors were ablated by heat and alkyl radicals with white light irradiation of the assembly, respectively. The assay in vivo showed that the self-assembly could effectively eliminate local lesions of solid tumors. This work provides new insights for improving the cure rate of tumors, which not only develops biomaterials adapted to the tumor microenvironment, but also proposes new therapies for complete elimination of solid tumors.
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