期刊
ACS APPLIED MATERIALS & INTERFACES
卷 14, 期 14, 页码 15982-15995出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c00761
关键词
tissue regeneration; bioactive porous scaffold; cartilage; 3D printing; binding peptide; hydrogel; gait analysis
资金
- NSF of China [52130302, 21961160721]
- National Key R&D Program of China [2016YFC1100300]
In this study, a bilayered porous scaffold with bioactive peptides was constructed for osteochondral repair. The scaffold showed promising therapeutic efficacy in promoting tissue regeneration and restoring animal gait behavior.
The treatment of cartilage injury and osteoarthritis has been a classic problem for many years. The idea of in situ tissue regeneration paves a way for osteochondral repair in vivo. Herein, a hydrogel scaffold linked with bioactive peptides that can selectively adsorb transforming growth factor beta 1 (TGF-/beta 1) was hypothesized to not only afford cell ingrowth space but also induce the endogenous TGF-beta 1 recruitment for chondrogenesis promotion. In this study, bilayered porous scaffolds with gelatin methacryloyl (GelMA) hydrogels as a matrix were constructed ria three-dimensional (3D) printing, of which the upper layer was covalently bound with bioactive peptides that can adsorb TGF-beta 1 for cartilage repair and the lower layer was blended with hydroxyapatite for subchondral regeneration. The scaffolds showed promising therapeutic efficacy proved by cartilage and osteogenic induction in vitro and osteochondral repair of rats in vivo. In particular, the animal gait behavior was recovered after the in situ tissue regeneration, and the corresponding gait analysis demonstrated the promotion of tissue regeneration induced by the porous hydrogels with the binding peptides.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据