期刊
ACADEMIC RADIOLOGY
卷 29, 期 11, 页码 E229-E239出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.acra.2022.03.002
关键词
chronic thromboembolic pulmonary hypertension (CTEPH); computed tomography (CT); histogram analysis
This study investigated the potential of using CT imaging features to evaluate changes in pulmonary circulatory dynamics in patients with CTEPH undergoing PEA surgery.
Rationale and Objectives: Pulmonary endarterectomy (PEA) is one of the most effective treatments for chronic thromboembolic pulmo-nary hypertension (CTEPH). Right heart catheterization (RHC) is the gold standard assessment for pulmonary circulatory dynamics. How-ever, computed tomography (CT) is less invasive than RHC and can elucidate some of the morphological changes caused by thromboembolism. We hypothesized that CT could facilitate the evaluation of heterogeneous pulmonary perfusion. This study investi-gated whether CT imaging features reflect the disease severity and changes in pulmonary circulatory dynamics in patients with CTEPH before and after PEA.Materials and Methods: This retrospective study included 58 patients with CTEPH who underwent PEA. Pre-PEA and post-PEA CT images were assessed for heterogeneity using CT texture analysis (CTTA). The CT parameters were compared with the results of the RHC and other clinical indices and analyzed with receiver operating characteristic curves analysis for patients with and without residual pulmo-nary hypertension (PH) (post-PEA mean pulmonary artery pressure > 25 mmHg).Results: CT measurements reflecting heterogeneity were significantly correlated with mean pulmonary artery pressure. Kurtosis, skew-ness, and uniformity were significantly lower, and entropy was significantly higher in patients with residual PH than patients without resid-ual PH. Area under the curve values of pre-PEA and post-PEA entropy between patients with and without residual PH were 0.71 (95% confidence interval 0.57-0.84) and 0.75 (0.63-0.88), respectively.Conclusion: Heterogeneity of lung density might reflect pulmonary circulatory dynamics, and CTTA for heterogeneity could be a less inva-sive technique for evaluation of changes in pulmonary circulatory dynamics in patients with CTEPH undergoing PEA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据