Semisolid Pharmaceutical Product Characterization Using Non-invasive X-ray Microscopy and AI-Based Image Analytics

Article Pharmacology & Pharmacy

Characterization of transport mechanisms for controlled release polymer membranes using focused ion beam scanning electron microscopy image-based modelling

Shawn Zhang et al.

Summary: Investigation of drug release mechanisms through polymer membrane in pellet formulation using FIB-SEM revealed significant impact of water content variation on controlled release performance. Image analysis and computational fluid dynamics simulations provided insights into porosity, pore size distribution, and flow permeability, allowing for quantitative comparison between different formulations and processing conditions. This analytical approach offers a method to evaluate the effects of permeation enhancers, solvents, and process conditions on controlled release formulations.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

Characterizing the Impact of Spray Dried Particle Morphology on Tablet Dissolution Using Quantitative X-Ray Microscopy

Shawn Zhang et al.

Summary: For oral solid dosage forms, the properties of disintegration and dissolution closely relate to the powders and particles used in their formulation. Three-dimensional non-invasive tomographic imaging plays an increasingly essential role in characterizing drug substances. The study used AI-based image analytics to quantify physical properties, revealing the root causes of differences in dissolution behavior between two tablets.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Chemistry, Medicinal

Microstructure, Quality, and Release Performance Characterization of Long-Acting Polymer Implant Formulations with X-Ray Microscopy and Quantitative AI Analytics

Karthik Nagapudi et al.

Summary: Long-acting implants are formulated using carriers and active pharmaceutical ingredients to achieve desired daily exposure, but characterizing these formulations using traditional methods can be time-consuming and costly. A novel technique involving high-resolution X-ray microscopy imaging and image-based quantification has been utilized to understand the impact of formulation and processes on polymer-based implant microstructures and performance. This new tool has the potential to advance the mechanistic understanding of drug-microstructure interactions and accelerate the development of long-acting implants.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Instruments & Instrumentation

Imaging Analysis Enables Differentiation of the Distribution of Pharmaceutical Ingredients in Tacrolimus Ointments

Mika Yoshimura Fuji et al.

APPLIED SPECTROSCOPY (2019)

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Article Chemistry, Multidisciplinary

Importance of air bubbles in the core of coated pellets: Synchrotron X-ray microtomography allows for new insights

J. Fahier et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Correction Pharmacology & Pharmacy

Generic Development of Topical Dermatologic Products: Formulation Development, Process Development, and Testing of Topical Dermatologic Products (vol 15, pg 41, 2013)

Rong-Kun Chang et al.

AAPS JOURNAL (2015)

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Semisolid Pharmaceutical Product Characterization Using Non-invasive X-ray Microscopy and AI-Based Image Analytics

相关参考文献

Characterization of transport mechanisms for controlled release polymer membranes using focused ion beam scanning electron microscopy image-based modelling

Characterizing the Impact of Spray Dried Particle Morphology on Tablet Dissolution Using Quantitative X-Ray Microscopy

Microstructure, Quality, and Release Performance Characterization of Long-Acting Polymer Implant Formulations with X-Ray Microscopy and Quantitative AI Analytics

Imaging Analysis Enables Differentiation of the Distribution of Pharmaceutical Ingredients in Tacrolimus Ointments

Importance of air bubbles in the core of coated pellets: Synchrotron X-ray microtomography allows for new insights

Generic Development of Topical Dermatologic Products: Formulation Development, Process Development, and Testing of Topical Dermatologic Products (vol 15, pg 41, 2013)

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