期刊
INTERNATIONAL JOURNAL OF UROLOGY
卷 23, 期 10, 页码 825-832出版社
WILEY
DOI: 10.1111/iju.13170
关键词
bone metastasis; cancer-induced bone pain; hypercalcemia; metastatic epidural spinal cord compression; pathological bone fractures; skeletal complications
资金
- NCATS NIH HHS [KL2 TR001421, UL1 TR001420] Funding Source: Medline
- NCI NIH HHS [U54 CA163124] Funding Source: Medline
- NIGMS NIH HHS [R01 GM099863] Funding Source: Medline
As a result of significant improvements in current therapies, the life expectancy of cancer patients with bone metastases has dramatically improved. Unfortunately, these patients often experience skeletal complications that significantly impair their quality of life. The major skeletal complications associated with bone metastases include: cancer-induced bone pain, hypercalcemia, pathological bone fractures, metastatic epidural spinal cord compression and cancer cachexia. Once cancer cells invade the bone, they perturb the normal physiology of the marrow microenvironment, resulting in bone destruction, which is believed to be a direct cause of skeletal complications. However, full understanding of the mechanisms responsible for these complications remains unknown. In the present review, we discuss the complications associated with bone metastases along with matched conventional therapeutic strategies. A better understanding of this topic is crucial, as targeting skeletal complications can improve both the morbidity and mortality of patients suffering from bone metastases.
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