期刊
CCS CHEMISTRY
卷 4, 期 6, 页码 1961-1976出版社
CHINESE CHEMICAL SOC
DOI: 10.31635/ccschem.021.202101630
关键词
fluorescent probe; heptamethine cyanine; second near-infrared emission; molecular design; biological application
资金
- National Basic Research Foundation of China [2017YFA0505202]
- National Natural Science Foundation of China [21676113, 21772054]
- Distinguished Young Scholar of Hubei Province [2018CFA079]
- 111 Project [B17019]
- Scholar Support Program of CCNU [090031101090002]
- A*STAR under its Advanced Manufacturing and Engineering Program [A2083c0051]
- Ministry of Education, Singapore [MOE-MOET2EP101200007]
- 619 National Creative Research Initiative programs of the 620 National Research Foundation of Korea - Korean government [2021R1A6A1A10039823]
In this work, a novel indolium-like heptamethine cyanine dye was designed and developed by installing indolium-derived polycyclic aromatic hydrocarbons on a conjugated polyene backbone. This dye showed bright fluorescent emission in the second near-infrared (NIR-II) window and had the capability of marking blood vessels in mice. Moreover, it exhibited strong absorption bands in the NIR range and high photothermal conversion efficiency, making it suitable for tumor-targeted photothermal therapy.
Heptamethine cyanine dyes, typified by indocyanine green, have been extensively employed as bioimaging indicators and theranostic agents. Significant efforts have been made to develop functional heptamethine cyanine dyes with outstanding bioimaging and theranostic utilities. In this work, we rationally designed and successfully developed a novel indolium-like heptamethine cyanine dye by installing indolium-derived polycyclic aromatic hydrocarbons on the terminal ends of a conjugated polyene backbone. This dye showed excellent photostability and showed bright fluorescent emission in the second near-infrared (NIR-II) window with a peak at approximately 1120 nm. Such long wavelength emission prompted a superior bioimaging resolution in vivo. In particular, this NIR-II dye had the remarkable capability of marking the blood vessels of the hindlimbs, abdomens, and brains of mice. More significantly, this dye involved a typical indolium-like heptamethine skeleton and exhibited two strong absorption bands in the 700-1300 nm NIR range, which endowed it with an intrinsic tumor-targeting capability and a high photothermal conversion efficiency (up to 68.2%), serving for the photothermal therapy of tumors under the guidance of NIR-II fluorescence imaging. This work provides an efficient design strategy for achieving indolium-like heptamethine cyanine dyes with further NIR-II emission. [GRAPHICS]
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