期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
卷 3, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpx.2021.100103
关键词
Water uptake; Swelling; Tablet performance; Pharmaceutical polymers; Amorphous solid dispersions; Gelling; Modelling
The functional behavior of tablets is strongly influenced by their manufacturing process and the choice of excipients, with water uptake and swelling being prerequisites for tablet disintegration and dispersion. The study investigated the impact of tablet composition, porosity, and pH of the test medium on water uptake and swelling, with the findings showing that HPMC and Kollidon VA64 inhibit water uptake and swelling due to the formation of a GPN.
The functional behaviour of tablets is strongly influenced by their manufacturing process and the choice of excipients. Water uptake and swelling are prerequisites for tablet disintegration, dispersion and hence active pharmaceutical ingredient (API) dissolution. High proportions of polymeric excipients in tablets, which are typically used as API carriers in amorphous solid dispersions (ASDs), may be challenging due to the formation of a gelling polymer network (GPN). In this study, systematic investigations into the formulation development of tablets containing polymeric and other excipients are performed by water uptake and swelling analysis. The impact of tablet composition and porosity as well as pH of the test medium are investigated. The pH affects the analysis results for Eudragit L100-55 and Eudragit EPO. HPMC and Kollidon VA64 inhibit water uptake and swelling of tablets due to the formation of a GPN. High tablet porosity, coarse particle size of the polymer and the addition of fillers and disintegrants can reduce the negative impact of a GPN on tablet performance. The application of lubricants slows down the analysed processes. Water uptake and swelling data are fitted to an empirical model obtaining four characteristic parameters to facilitate the simple quantitative assessment of varying tablet formulations and structural properties.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据