期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
卷 3, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpx.2021.100085
关键词
Dual centrifugation; Solid lipid nanoparticles; Lipid dispersion; Nanoparticles; Formulation screening; Lipid emulsion
资金
- Ministry of Science and Culture (MWK) of Lower Saxony, Germany
A new manufacturing process, dual centrifugation, is introduced for preparing solid lipid nanoparticles, which can complete the emulsification process in a short time and achieve particle sizes below 200 nm with a narrow, monomodal size distribution.
A promising strategy to formulate poorly water-soluble active pharmaceutical ingredients (APIs) is the application of these substances in solid lipid nanoparticles. These drug carrier systems are commonly prepared by high-pressure homogenization above the melting temperature of the utilized lipid. While being very useful for large-scale production this method is quite resource-consuming and does not allow simultaneous processing of multiple samples, e.g. for screening purposes. For this reason, an alternative manufacturing process, dual centrifugation, is introduced to prepare solid lipid nanoparticles. The ingredients of the dispersions were directly weighed into 2 mL vessels at room temperature without the need to prepare a pre-mix emulsion. Due to an additional rotation of the samples in the heated centrifuge as well as the addition of grinding media an intensive stressing of the samples was achieved. The emulsification process was finished within 10 min with sample temperatures of up to 90 degrees C being obtained. Dependent on the process set-up like grinding media size, filling ratio or process temperature and the composition of the lipid formulation, the achieved particles sizes were below 200 nm and had a narrow, monomodal size distribution.
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