4.0 Article

Sickle Cell Trait and SARS-CoV-2-Induced Rhabdomyolysis: A Case Report

期刊

AMERICAN JOURNAL OF CASE REPORTS
卷 23, 期 -, 页码 -

出版社

INT SCIENTIFIC INFORMATION, INC
DOI: 10.12659/AJCR.934220

关键词

Acute Kidney Injury; COVID-19; Rhabdomyolysis; Sickle Cell Trait

向作者/读者索取更多资源

This study presents a case of rhabdomyolysis caused by SARS-CoV-2 infection. The patient had unknown sickle cell trait and developed acute kidney injury, requiring acute hemodialysis. Pathological examination confirmed rhabdomyolysis injury, but no viral traces were found in the kidney biopsy samples. The mechanisms of SARS-CoV-2-induced rhabdomyolysis are discussed, and it is suggested to test for sickle cell trait in African patients.
Objective: Rare coexistence of disease or pathology Background: Rhabdomyolysis is a syndrome characterized by muscle necrosis and the subsequent release of intracellular muscle constituents into the bloodstream. Although the specific cause is frequently evident from the history or from the immediate events, such as a trauma, extraordinary physical exertion, or a recent infection, sometimes there are hidden risk factors that have to be identified. For instance, individuals with sickle cell trait (SCT) have been reported to be at increased risk for rare conditions, including rhabdomyolysis. Moreover, there have been a few case reports of SARS-CoV-2 infection-related rhabdomyolysis. Case Report: We present a case of a patient affected by unknown SCT and admitted with SARS-CoV-2 pneumonia, who suffered non-traumatic non-exertional rhabdomyolysis leading to acute kidney injury (AKI), requiring acute hemodialysis (HD). The patients underwent 13 dialysis session, of which 12 were carried out using an HFR-Supra H dialyzer. He underwent kidney biopsy, where rhabdomyolysis injury was ascertained. No viral traces were found on kidney biopsy samples. The muscle biopsy showed the presence of an open nucleolus in the muscle cell, which was consistent with virus-infected cells. After 40 days in the hospital, his serum creatinine was 1.62 mg/dL and CPK and Myoglobin were 188 U/L and 168 ng/mL, respectively; therefore, the patient was discharged. Conclusions: SARS-CoV-2 infection resulted in severe rhabdomyolysis with AKI requiring acute HD. Since SARS-CoV-2 infection can trigger sickle-related complications like rhabdomyolysis, the presence of SCT needs to be ascertained in African patients.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.0
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据