Intraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental Modeling

Article Endocrinology & Metabolism

Intraperitoneal insulin administration in pigs: effect on circulating insulin and glucose levels

Ilze Dirnena-Fusini et al.

Summary: This study investigated the pharmacokinetics and pharmacodynamics of intraperitoneal insulin boluses in pigs, finding varying effects on blood glucose and insulin levels based on different doses. Intraperitoneal insulin infusion showed differences compared to subcutaneous infusion methods.

BMJ OPEN DIABETES RESEARCH & CARE (2021)

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Article Biochemistry & Molecular Biology

Modeling Intraperitoneal Insulin Absorption in Patients with Type 1 Diabetes

Michele Schiavon et al.

Summary: Standard insulin therapy for type 1 diabetes involves subcutaneous administration of exogenous insulin, but intraperitoneal insulin administration has been shown to be a valid alternative with potential benefits. This study aimed to develop a mathematical model describing the absorption and distribution of insulin after intraperitoneal administration, using data from T1D patients treated with implanted pumps. The selected model involved a linear, two-compartment model for insulin absorption in the IP space, coupled with a two-compartment model for whole-body insulin kinetics.

METABOLITES (2021)

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Article Engineering, Biomedical

Artificial Pancreas: In Silico Study Shows No Need of Meal Announcement and Improved Time in Range of Glucose With Intraperitoneal vs. Subcutaneous Insulin Delivery

Chiara Toffanin et al.

Summary: Contemporary Artificial Pancreas systems consist of subcutaneous glucose sensors, SC insulin pumps, and control algorithms. Intraperitoneal insulin delivery offers faster response to glycemic disturbances and shows significant improvements in glucose control compared to SC AP.

IEEE TRANSACTIONS ON MEDICAL ROBOTICS AND BIONICS (2021)

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Article Medicine, General & Internal