3.8 Article

Intraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental Modeling

期刊

JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
卷 17, 期 3, 页码 751-756

出版社

SAGE PUBLICATIONS INC
DOI: 10.1177/19322968221076559

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intraperitoneal insulin delivery; closed-loop; type 1 diabetes; insulin kinetics

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This study develops a compartmental model of intraperitoneal insulin kinetics and proves the peritoneum to be a virtual space for insulin delivery.
BackgroundIntraperitoneal insulin delivery has proven to safely overcome a major limit of subcutaneous delivery-meal announcement-and has been able to optimize glycemic control in adults under controlled experimental conditions. In addition, intraperitoneal delivery avoids peripheral hyperinsulinemia resulting from the subcutaneous route and restores a physiological liver gradient. MethodsRelying on a unique data set of intraperitoneal closed-loop insulin delivery obtained with a Model Predictive Controller (MPC), we develop a compartmental model of intraperitoneal insulin kinetics, which, once included in the UVa/Padova T1D simulator, will facilitate the investigation of various control strategies, for example, the simpler Proportional Integral Derivative controller versus MPC. ResultsIntraperitoneal insulin kinetics can be described with a 2-compartment model including liver and plasma. ConclusionIntraperitoneal insulin transit is fast enough to render irrelevant the addition of a peritoneal compartment, proving the peritoneum being a virtual-not actual-transit space for insulin delivery.

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