期刊
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
卷 92, 期 11, 页码 617-632出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/09553002.2015.1136854
关键词
Auger emitters; Auger electrons; DNA double-strand breaks; Auger endoradiotherapy
To identify the emergence of the recognition of the potential of the Auger effect for clinical application, and after tracing the salient milestones towards that goal, to evaluate the status quo and future prospects. It was not until 40 years after the discovery of Auger electrons, that the availability of radioactive DNA precursors enabled the biological power, and the clinical potential, of the Auger effect to be appreciated. Important milestones on the path to clinical translation have been identified and reached, but hurdles remain. Nevertheless the potential is still evident, and there is reasonable optimism that the goal of clinical translation is achievable.
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