期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 65, 期 16, 页码 807-815出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2016.1163561
关键词
Collagen; mineralization; nanofibers; nanohydroxyapatite; osteoblasts
资金
- European Union of European Social Fund through the Warsaw University of Technology Development Programme
- National Science Center [DEC-2011/01/M/ST8/07742]
Nanoengineered biodegradable constructs based on synthetic and natural polymers enriched with hydroxyapatite (HA) nanoparticles have been found to mimic the extracellular matrix of bone tissue. The main objective of this study was to create biocomposite nanostructured scaffolds by incorporating collagen and HA nanoparticles into poly(L-lactic acid)-co-poly(epsilon-caprolactone) by electrospinning. The fiber diameter of the composite PLCL/Col and PLCL/Col/HA fibers was smaller compared to PLCL. In vitro biocompatibility of the scaffolds studied using human fetal osteoblasts and EDX analysis showed high deposition of calcium on PLCL/Col/HA. The results shows that PLCL/Col/HA nanofibrous constructs have huge potential as substrates for bone regeneration. [GRAPHICS]
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