期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 66, 期 8, 页码 398-409出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2016.1233418
关键词
Biomaterials; cytotoxicity; drug delivery systems; hydrogels; IPN polymers; stimuli response
资金
- National Natural Science Foundation of China [21572123, 21273142, 21172138]
- Fundamental Research Funds for the Central Universities [GK201601003]
Novel poly(N-isopropylacrylamide)/carboxymethyl chitosan/multiwalled carbon nanotube semi-interpenetrating nanohybrid hydrogels were prepared, and the chemical structure and morphology were characterized. The prepared hydrogels showed temperature and pH dual-responsiveness, and the one containing multiwalled carbon nanotubes (MWCNTs)-COOH possessed high maximal swelling ratios. The phase transition produced at pH of 6.8-7.4 and temperature of 35-40 degrees C, hinging on the system compositions and charge ratios. The hydrogels were used to load hydrophilic anticancer drug, with high entrapped efficiency of about 44%. The drug release changed with temperature, pH, and MWCNTs-COOH contents. The designed hydrogels can be used for site-specific target delivery of protein or hydrophilic anticancer drug.
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