期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 509, 期 1-2, 页码 391-399出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2016.06.006
关键词
Resveratrol (RES); Cocrystal; Solubility; Tabletability; Mechanical property
资金
- Macao Science and Technology Development Fund [112/2013/A3]
- Matching Grant from University of Macau [MRG031/ZY/2015/ICMS]
- Department of Pharmaceutics at the University of Minnesota
Two new 1: 1 cocrystals of resveratrol (RES) with 4-aminobenzamide (RES-4ABZ) and isoniazid (RES-ISN) were synthesized by liquid assisted grinding (LAG) and rapid solvent removal (RSR) methods using ethanol as solvent. Their physiochemical properties were characterized using PXRD, DSC, solid state and solution NMR, FT-IR, and HPLC. Pharmaceutically relevant properties, including tabletability, solubility, intrinsic dissolution rate, and hygroscopicity, were evaluated. Temperature-composition phase diagram for RES-ISN cocrystal system was constructed from DSC data. Both cocrystals show higher solubility than resveratrol over a broad range of pH. They are phase stable and non-hygroscopic even under high humidity conditions. Importantly, both cocrystals exhibit improved solubility and tabletability compared with RES, which make them more suitable candidates for tablet formulation development. (C) 2016 Elsevier B.V. All rights reserved.
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