期刊
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
卷 33, 期 48B, 页码 101-107出版社
SCIENCEDOMAIN INT
DOI: 10.9734/JPRI/2021/v33i48B33266
关键词
Hemochromatosis; heart failure; iron overload; thalassemia
Hemochromatosis is the abnormal accumulation of iron in various organs of the body due to increased gut absorption of iron and low hepcidin yield. Cardiac hemochromatosis is identified as the presence of cardiac dysfunction caused by increased iron accumulation in the heart leading to heart failure, which is secondary to thalassemia major. Regular monitoring of serum iron, ferritin, and echocardiography is essential for thalassemia major patients to prevent and treat heart failure caused by iron overload. Early diagnosis and intervention are crucial in preventing and treating cardiac involvement in secondary hemochromatosis due to thalassemia major.
Hemochromatosis is defined as abnormal accumulation of iron in various organs of the body such as liver, pancreas, skin, joints, heart due to raised gut absorption of iron due to low hepcidin yield. Hemochromatosis is secondary to thalassemia major in this case. In the absence of other concurrent processes, cardiac hemochromatosis is identified as the presence of cardiac dysfunction owing to increased iron accumulation in the heart leading to heart failure. Unique: Cardiac involvement in secondary hemochromatosis due to thalassemia major. Take Away lesson: Regular monitoring of serum iron, ferritin, echocardiographic monitoring among thalassemia major patients is essential. Despite the fact that heart failure due to iron overload could be fatal, early diagnosis and intervention could prevent and treat the disease.
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