期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 509, 期 1-2, 页码 123-134出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2016.05.033
关键词
Powder feeding; Micro feeding; Continuous blending; Vibratory sieve; Feed rate robustness; DEM; Compartment model
资金
- Austrian COMET Program under Austrian Federal Ministry of Transport, Innovation and Technology (BMVIT)
- Austrian Federal Ministry of Economy, Family and Youth (BMWFJ)
- Province of Styria (Styrian Business Promotion Agency, SFG)
- National Science Foundation Engineering Research Center on Structured Organic Particulate Systems [NSF-ECC 0540855]
Precise and effective feeding of small powder quantities remains a challenge in many fields, including pharmaceutical development and production. This paper demonstrates that a simple feeding principle can be applied to accomplish stable micro feeding (<100 mg/s) and describes a gravimetric powder feeding system with a vibratory sieve mounted on a chute. Feeding was induced via vertical vibrations that can be adjusted within a broad range of frequencies and amplitudes. The feeding system was studied using different frequencies, amplitudes, sieves and powder properties. Feeding was characterized by means of a dynamic scale and high-speed camera recordings. The feeding system provided effective powder feeding even in a range of 1-2 mg/s. It was shown that powder properties require special attention when the vibratory sieve-chute system operates at higher feed rates (or feeding times >30 min), i.e., feeding at a higher throughput. A combination of discrete element method (DEM) simulations and compartment population balance model (PBM) was used to incorporate the proposed micro feed system into a continuous powder mixer (Gerike GCM250; Gerike Holding LTD., Regensdorf, Switzerland). It illustrates how oscillating feeding rates (the latter is a characteristic of the studied micro feeding system) affect the content uniformity of low dose blends, i.e., powder mixtures with a relatively low fraction of active pharmaceutical ingredient. (C) 2016 Elsevier B.V. All rights reserved.
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