Amplification-Free Identification and Determination of Nucleic Acids by Surface Plasmon Resonance and Surface-Enhanced Raman Spectroscopy

This review discusses contemporary approaches to designing sensory systems for the identification and determination of nucleic acids (NAs) without amplifying target molecules. Here we summarize the data about methods based on surface plasmon resonance and surface-enhanced Raman spectroscopy, as well as their possibilities, limitations, and prospects for further development.

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This review discusses contemporary approaches to designing sensory systems for the identification and determination of nucleic acids without amplifying target molecules, focusing on methods based on surface plasmon resonance and surface-enhanced Raman spectroscopy, and their possibilities, limitations, and prospects for further development.