期刊
INFECTION DISEASE & HEALTH
卷 27, 期 3, 页码 119-128出版社
ELSEVIER INC
DOI: 10.1016/j.idh.2022.01.002
关键词
Clostridioides difficile; Antibiotic; Infection control; Time series data; Hospital
This study investigated the association between Clostridioides difficile infection (CDI), antibiotic use, and infection control interventions. The results showed a significant reduction in the rate of community-acquired CDI in the adult ICU during the implementation of an antibiotic stewardship program. The CDI rates remained stable in the rest of the hospital, and there was also a significant reduction in antibiotic consumption throughout the hospital.
Background: To investigate the association between Clostridioides difficile infection (CDI), antibiotic use, and infection control interventions, during an antibiotic stewardship program (ASP) implemented in a tertiary-care hospital in Greece from 2013 to 2018. Methods: Analysis was applied for the following monthly indices: 1. consumption of antibiotics; 2. use of hand hygiene disinfectant solutions; 3. percentage of isolations of patients either with multidrug-resistant (MDR) bacteria, or CDI, or admitted from another hospital; and 4. percentage of patients with CDI divided into two groups: community-acquired CDI (CACDI) and hospital-associated CDI (HACDI) (onset <72 h and >72 h after admission, respectively). Results: During the study, a significant reduction in CACDI rate from 0.3%/admissions [95% CI 0.1-0.6] to 0.1%/admissions [95% CI 0.0-0.3] (p-value Z 0.035) was observed in adults ICU, while CDI rates were stable in the rest of the hospital. Antibiotic consumption showed a significant reduction in total hospital, from 91.7 DDDs [95% CI 89.7-93.7] to 80.1 DDDs [95% CI 79.1
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