期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 510, 期 2, 页码 516-523出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2016.01.061
关键词
Poly(methacrylic acid); Hydroxyapatite; Biocompatibility; Dental material
资金
- Sectorial Operational Programme Human Resources Development of the Romanian Ministry of Labour, Family and Social Protection [POSDRU/107/1.5/S/76903]
The use of methacrylic acid (MAA) in medicine was poorly investigated in the past but can be of great importance because the incorporation of hydroxyapatite (HA) can lead to new composite materials with good properties due to the strong electrostatic interactions between carboxylate groups of polymer and Ca2+ ions from HA. The scope of this study was to determine the potential of using composite materials based on poly(methacrylic acid) (PMAA) and hydroxyapatite in dentistry. Two routes of synthesis were taken into account: i) HA was synthesised in situ and ii) commercial HA was used. Fourier transform infrared spectroscopy and X-ray diffraction were used for compositional assessments. Scanning electron microscopy was performed to determine the morphology and differential thermal analysis (DTA) coupled with thermogravimetric analysis (TG) was used to study the thermal behaviour and to observe quantitative changes. In-vitro tests were also performed in order to evaluate the biocompatibility of both PMAA/HA composites by monitoring the development potential of human endothelial cells using MTT assay and fluorescent microscopy. (C) 2016 Elsevier B.V. All rights reserved.
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