期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 499, 期 1-2, 页码 263-270出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2015.12.067
关键词
Magnetic Resonance Imaging (MRI); X-ray microtomography (mu CT, Micro-CT); Biorelevant stress test dissolution; Quetiapine controlled release tablets; Dry granulation; High shear granulation; Direct compression
Purpose of the research: The purpose of the research was to investigate the effect of the manufacturing process of the controlled release hydrophilic matrix tablets on their hydration behavior, internal structure and drug release. Direct compression (DC) quetiapine hemifumarate matrices and matrices made of powders obtained by dry granulation (DG) and high shear wet granulation (HS) were prepared. They had the same quantitative composition and they were evaluated using X-ray microtomography, magnetic resonance imaging and biorelevant stress test dissolution. Principal results: Principal results concerned matrices after 2 h of hydration: (i) layered structure of the DC and DG hydrated tablets with magnetic resonance image intensity decreasing towards the center of the matrix was observed, while in HS matrices layer of lower intensity appeared in the middle of hydrated part; (ii) the DC and DG tablets retained their core and consequently exhibited higher resistance to the physiological stresses during simulation of small intestinal passage than HS formulation. Major conclusions: Comparing to DC, HS granulation changed properties of the matrix in terms of hydration pattern and resistance to stress in biorelevant dissolution apparatus. Dry granulation did not change these properties-similar hydration pattern and dissolution in biorelevant conditions were observed for DC and DG matrices. (C) 2015 Elsevier B.V. All rights reserved.
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