期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 505, 期 1-2, 页码 369-375出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2016.04.023
关键词
Nuclear imaging; Breast cancer; I-131; Radiolabeling; Phthalocyanine; Dual imaging
资金
- Scientific and Technological Research Council of Turkey, TUBITAK [114Z430]
A near IR absorbing phthalocyanine bearing four binaphtyl group has been synthesized in order to investigate its cytotoxicity and intracellular uptake of sensitizer on MCF-7 (human breast cancer), MDAH (ovarian cancer), HeLa (human epitheloid cervix carcinoma), EMT-6 (mouse breast cancer) and WI-38 (human fibroblast lung) cell lines. ZnPc showed four time higher intracellular uptake in carcinoma cells (MCF-7) than normal (WI-38) cell lines. With the aim of studying in detail the biodistribution feature and tumor nuclear imaging capacity, ZnPc was also labeled with I-131. The efficiency of radiolabeled compound was 95 +/- 4.6%. In addition, ZnPc reveals to be very efficient singlet oxygen generators (Phi Delta = 0.612 in DMSO) and promising PS for PDT application. In vitro fluorescence imaging study with MCF-7 cells showed that ZnPc localized in cytoplasm of the cells. This results showed that synthesized ZnPc is promising candidate for dual fluorescence/nuclear imaging breast cancer and shows potential PS for PDT application. (C) 2016 Elsevier B.V. All rights reserved.
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