期刊
JOURNAL OF ORAL BIOSCIENCES
卷 64, 期 1, 页码 8-17出版社
ELSEVIER
DOI: 10.1016/j.job.2022.01.008
关键词
Dentistry; Bone; Physiology; Pathology; Therapy
资金
- Japan Society for the Promotion of Science (JSPS)
- Japan Science and Technology Agency
- Daiichi Sankyo Company
- Daiichi Sankyo Foundation of Life Science
- Japan Rheumatism Foundation
- LIFE SCIENCE FOUNDATION OF JAPAN
- Lotte Research Promotion Grant
- Meiji Yasuda Life Foundation
- Mitsui Life Social Welfare Foundation
- Naito Foundation
- Suzuken Memorial Foundation
- Takeda Science Foundation
- Asahi Glass Foundation
- Sumitomo Foundation
- Uehara Memorial Foundation
- Secom Science and Technology Foundation (SSTF)
- Novartis
This article provides an overview of the physiology and pathology of oral bone, with a focus on recent advancements achieved through novel techniques. These advancements have contributed to a better understanding of the mechanisms and potential therapies for oral diseases.
Background: The cranial bones provide a structural framework to the head and face, protecting the organs inside. The cranium is endowed with mobility through the temporomandibular joints, with which many oral functions are performed. To exert these functions, the cranial bones undergo a continuous maintenance process of bone formation and resorption, bone remodeling. The remodeling of cranial bones is influenced by the physiological or pathological conditions they are subjected, including periodontitis and tumor. Therefore, oral bone biology has been investigated from multiple viewpoints. Highlights: We overview the physiology and pathology of the bone, centering on oral biology. Recently, many valuable insights have been obtained using novel techniques, including X-ray diffractometry, high -resolution microscopy, DNA/RNA sequencing, and mouse genetics. These insights include hydroxyapatite crystal alignment, cell lineage tracing, bone cell activity, biomechanics, the mechanisms underlying oral diseases and potential therapies for these diseases. These findings have advanced the oral bone biology research field and provided a better awareness of that which is currently known, and that which needs to be investigated. Conclusion: Based on the current state of accumulated knowledge, further progress is needed for obtaining a comprehensive picture of oral biology to greatly improve the level of clinical practices. (C) 2022 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved.
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