期刊
JOURNAL OF ORAL BIOSCIENCES
卷 64, 期 1, 页码 155-158出版社
ELSEVIER
DOI: 10.1016/j.job.2021.12.006
关键词
Obesity; Taste; Gustducin; Phospholipase C beta 2 (PLC beta 2); Transient receptor potential channel M5 (Trpm5)
资金
- Monell Institutional Funds
This study shows that taste-signaling proteins are dysregulated in the jejunal tissues of patients with extreme obesity, suggesting their involvement in obesity.
Taste-signaling proteins, which are expressed throughout the digestive tract, are involved in regulating metabolism and immunity. This study aimed to determine if these genes are expressed and altered in jejunal tissues from patients with extreme obesity who received bariatric surgery. Reverse transcription polymerase chain reaction revealed that phospholipase C beta 2 and transient receptor potential channel M5 expression was downregulated in the jejunum of patients with a body mass index above 50, whereas gustducin expression remained unchanged. Our data suggest that taste-signaling dysregulation might contribute to obesity. (C) 2022 Published by Elsevier B.V. on behalf of Japanese Association for Oral Biology.
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