期刊
CURRENT HYPERTENSION REVIEWS
卷 17, 期 3, 页码 245-249出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573402117666210121100936
关键词
Arterial stiffness; blood pressure; BMI; young; healthy; cardiovascular diseases (CVDs)
The study revealed significantly increased pulse pressure, baPWV, and cfPWV in individuals with low BMI compared to those with normal BMI. There was a significant negative correlation between BMI and central arterial PWV. Multiple regression analysis showed robust associations between BMI and cf-PWV and baPWV even after adjusting for potential confounders.
Background: Increased arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. It is unknown whether low BMI has any detrimental effect on the arterial wall during young age. Objectives: The present study was aimed to determine if low BMI can increase arterial stiffness in young, healthy individuals. Methods: A cross-sectional study was conducted on young, healthy subjects (n=100) with low BMI <18.5 (n=50) and normal BMI: 18.5-24.9 (n=50) with ages ranging between 15-23 years. BMI, heart rate, blood pressure, and arterial stiffness indices such as regional pulse wave velocity (PWV) between brachial-ankle (baPWV), carotid-femoral (cfPWV), heart-ankle (haPWV), heart brachial (hbPWV) were measured. Results: A significantly increased pulse pressure (p=0.014), baPWV (1059.2 +/- 140.26 cm/s vs 994.66 +/- 129.23 cm/s; p=0.019) and cfPWV (641.03 +/- 113.83 cm/s vs 583.96 +/- 120.48 cm/s; p=0.017) was found in individuals with low BMI than normal BMI group. There was a significant negative correlation between BMI and central arterial PWV. Further multiple regression analysis showed that BMI was robustly associated with cf-PWV (p=0.004) and baPWV (p=0.016) even after multiple adjustments with potential confounders using several models. Conclusions: These findings show a significant increased aortic stiffness and pulse pressure in low BMI subjects compared to those with normal BMI. Low BMI was inversely and independently associated with central arterial or aortic stiffness. These findings suggest that low BMI may be a risk factor for aortic stiffness in young, healthy individuals.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据