期刊
INTERNATIONAL JOURNAL OF OPTOMECHATRONICS
卷 10, 期 1, 页码 53-62出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15599612.2016.1149896
关键词
vertical indentation; cell stiffness; cell mechanics; optical tweezers; Cancer cell
资金
- Applied Physics section of the International Centre for Theoretical Physics (ICTP), Trieste
- ICTP-STEP program
- ERC Ideas Program [269051]
- European Research Council (ERC) [269051] Funding Source: European Research Council (ERC)
We studied the lateral forces arising during the vertical indentation of the cell membrane by an optically trapped microbead, using back focal plane interferometry to determine force components in all directions. We analyzed the cell-microbead interaction and showed that indeed the force had also lateral components. Using the Hertz model, we calculated and compared the elastic moduli resulting from the total and vertical forces, showing that the differences are important and the total force should be considered. To confirm our results we analyzed cells from two breast cancer cell lines: MDA-MB-231 and HBL-100, known to have different cancer aggressiveness and hence stiffness.
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