4.4 Review

A survey of physical methods for studying nuclear mechanics and mechanobiology

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Mechanical Forces in Nuclear Organization

Yekaterina A. Miroshnikova et al.

Summary: Cells generate and sense mechanical forces to control cell fate and maintain genome integrity.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2022)

Article Biochemistry & Molecular Biology

Nuclear Deformation Causes DNA Damage by Increasing Replication Stress

Pragya Shah et al.

Summary: During cancer metastasis, cancer cells migrate through narrow spaces, leading to nuclear deformation, nuclear envelope rupture, and DNA damage. This damage, associated with replication stress, increases genomic instability and could contribute to tumorigenesis.

CURRENT BIOLOGY (2021)

Article Biochemistry & Molecular Biology

DNA damage alters nuclear mechanics through chromatin reorganization

Alia dos Santos et al.

Summary: DNA double-strand breaks lead to genomic instability, affecting the mechanical properties of the nucleus and potentially contributing to drug resistance. Investigation using Atomic Force Microscopy showed that reducing nuclear stiffness and tension can improve DNA repair efficiency and protect against further DNA damage accumulation.

NUCLEIC ACIDS RESEARCH (2021)

Article Chemistry, Multidisciplinary

Nuclear Stiffness Decreases with Disruption of the Extracellular Matrix in Living Tissues

Kaitlin P. McCreery et al.

Summary: The reciprocal interactions between the cell nucleus and the extracellular matrix influence macroscale tissue phenotype changes. Enzymatic disruption of the tissue matrix is hypothesized to result in softer tissue, impacting the stiffness of embedded cell and nuclear structures. An atomic force microscopy needle-tip probe technique is expanded to measure nuclear and cell membrane stiffness in native tissue without perturbing the tissue structure.
Article Chemistry, Multidisciplinary

Image-Based Elastography of Heterochromatin and Euchromatin Domains in the Deforming Cell Nucleus

Soham Ghosh et al.

Summary: The study introduces nuclear elastography technology to quantify the relative elasticity of heterochromatin and euchromatin domains within the cell nucleus; experiments reveal rapid changes in relative elasticity between these two regions during cellular deformation; disruption of specific nuclear membrane proteins affects intranuclear elasticity distribution, leading to similarities between heterochromatin and euchromatin.
Article Biochemistry & Molecular Biology

In situ AFM detection of the stiffness of the in situ exposed cell nucleus

Kun Wang et al.

Summary: The stiffness of the cell nucleus is a critical biomechanical property that plays important roles in cell behaviors and functions. This study developed a strategy for in situ detecting the stiffness of the cell nucleus via AFM, revealing that both the intact cell nucleus and the exposed nucleus have different stiffness compared to nonnuclear regions. This simple and effective strategy holds promise for wide application in studying cell biomechanics.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Article Cell Biology

Spatial distribution of lamin A/C determines nuclear stiffness and stress-mediated deformation

Luv Kishore Srivastava et al.

Summary: The study found that nuclear stiffness is crucial for cellular response to stresses, with lamin A/C possibly playing a role, and nuclear compression is anisotropic. Additionally, the distribution of lamin A/C in the nuclear membrane may impact local nuclear deformations.

JOURNAL OF CELL SCIENCE (2021)

Article Biophysics

Depletion of HP1α alters the mechanical properties of MCF7 nuclei

Susav Pradhan et al.

Summary: This study investigates the changes in material properties of nuclei extracted from MCF7 cells after knockdown of HP1α, showing that HP1α depletion significantly reduces the apparent Young's moduli of the cell nuclei. Additionally, different mechanical properties of the nuclei were observed when using different techniques, indicating that various components within the nuclei impact the overall mechanical response differently.

BIOPHYSICAL JOURNAL (2021)

Review Cell Biology

Visualizing the Invisible: Advanced Optical Microscopy as a Tool to Measure Biomechanical Forces

Chad M. Hobson et al.

Summary: Mechanical force plays a crucial role in biology, from tissue morphogenesis during embryo development to mechanotransduction at the cell surface. Advanced microscopy techniques offer enhanced resolution and imaging depth, but accessing the necessary expertise and instrumentation remains a challenge.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Multidisciplinary Sciences

Optical tweezers in single-molecule biophysics

Carlos J. Bustamante et al.

Summary: This paper introduces optical tweezers as a method for single-molecule manipulation studies, discussing in detail the physical principles, instrument characteristics, and applications. Key aspects such as calibration, operating modes, and experimental geometries of optical tweezers are explored, along with their applications in protein-nucleic acid interactions, protein/RNA folding, and molecular motors, as well as potential future trends.

NATURE REVIEWS METHODS PRIMERS (2021)

Article Engineering, Biomedical

Actomyosin, vimentin and LINC complex pull on osteosarcoma nuclei to deform on micropillar topography

Nayana Tusamda Wakhloo et al.

BIOMATERIALS (2020)

Article Chemistry, Physical

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

Ashley J. Earle et al.

NATURE MATERIALS (2020)

Article Biophysics

TENSCell: Imaging of Stretch-Activated Cells Reveals Divergent Nuclear Behavior and Tension

Benjamin Seelbinder et al.

BIOPHYSICAL JOURNAL (2020)

Article Biochemistry & Molecular Biology

Nesprin-2 accumulates at the front of the nucleus during confined cell migration

Patricia M. Davidson et al.

EMBO REPORTS (2020)

Review Cell Biology

Lamin A/C Mechanotransduction in Laminopathies

Francesca Donnaloja et al.

Article Chemistry, Physical

Cortical cell stiffness is independent of substrate mechanics

Johannes Rheinlaender et al.

NATURE MATERIALS (2020)

Article Biochemical Research Methods

A comparison of microfluidic methods for high-throughput cell deformability measurements

Marta Urbanska et al.

NATURE METHODS (2020)

Review Cell Biology

The Emerging Roles of Heterochromatin in Cell Migration

Gabi Gerlitz

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Cell Biology

Direct evidence that tumor cells soften when navigating confined spaces

Carmela Rianna et al.

MOLECULAR BIOLOGY OF THE CELL (2020)

Article Biotechnology & Applied Microbiology

Chromatin rigidity provides mechanical and genome protection

Andrew D. Stephens

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2020)

Article Biophysics

Isolated nuclei stiffen in response to low intensity vibration

Joshua Newberg et al.

JOURNAL OF BIOMECHANICS (2020)

Article Biochemical Research Methods

Nuclear plasticity increases susceptibility to damage during confined migration

Abhishek Mukherjee et al.

PLOS COMPUTATIONAL BIOLOGY (2020)

Article Biotechnology & Applied Microbiology

Nanomechanical properties of enucleated cells: contribution of the nucleus to the passive cell mechanics

Yuri M. Efremov et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

Article Multidisciplinary Sciences

The nucleus acts as a ruler tailoring cell responses to spatial constraints

A. J. Lomakin et al.

SCIENCE (2020)

Review Cell Biology

Chromatin's physical properties shape the nucleus and its functions

Andrew D. Stephens et al.

CURRENT OPINION IN CELL BIOLOGY (2019)

Article Cell Biology

Mechanical Function of the Nucleus in Force Generation during Epithelial Morphogenesis

Arnaud Ambrosini et al.

DEVELOPMENTAL CELL (2019)

Article Multidisciplinary Sciences

Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints

Farid Alisafaei et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Cell Biology

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

Andrew D. Stephens et al.

MOLECULAR BIOLOGY OF THE CELL (2019)

Review Biochemical Research Methods

Brillouin microscopy: an emerging tool for mechanobiology

Robert Prevedel et al.

NATURE METHODS (2019)

Article Multidisciplinary Sciences

Nuclei deformation reveals pressure distributions in 3D cell clusters

Adele Khavari et al.

PLOS ONE (2019)

Article Cell Biology

Vimentin protects cells against nuclear rupture and DNA damage during migration

Alison E. Patteson et al.

JOURNAL OF CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading

Hamish T. J. Gilbert et al.

NATURE COMMUNICATIONS (2019)

Article Chemistry, Multidisciplinary

Proliferation of Cells with Severe Nuclear Deformation on a Micropillar Array

Ruili Liu et al.

LANGMUIR (2019)

Article Cell Biology

Local, transient tensile stress on the nuclear membrane causes membrane rupture

Qiao Zhang et al.

MOLECULAR BIOLOGY OF THE CELL (2019)

Review Engineering, Mechanical

Nuclear mechanics duringand after constricted migration

Yuntao Xia et al.

ACTA MECHANICA SINICA (2019)

Article Cell Biology

The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells

Vincent J. Tocco et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Review Cell Biology

Separate roles for chromatin and lamins in nuclear mechanics

Andrew D. Stephens et al.

NUCLEUS (2018)

Review Cell Biology

Separate roles for chromatin and lamins in nuclear mechanics

Andrew D. Stephens et al.

NUCLEUS (2018)

Article Biophysics

Widefield High Frame Rate Single-Photon SPAD Imagers for SPIM-FCS

Jan Buchholz et al.

BIOPHYSICAL JOURNAL (2018)

Article Cell Biology

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

Andrew D. Stephens et al.

MOLECULAR BIOLOGY OF THE CELL (2018)

Article Cell Biology

Constricted migration increases DNA damage and independently represses cell cycle

Charlotte R. Pfeifer et al.

MOLECULAR BIOLOGY OF THE CELL (2018)

Review Cell Biology

Emerging views of the nucleus as a cellular mechanosensor

Tyler J. Kirby et al.

NATURE CELL BIOLOGY (2018)

Article Biochemical Research Methods

A comparison of methods to assess cell mechanical properties

Pei-Hsun Wu et al.

NATURE METHODS (2018)

Letter Biochemical Research Methods

Water content, not stiffness, dominates Brillouin spectroscopy measurements in hydrated materials

Pei-Jung Wu et al.

NATURE METHODS (2018)

Article Multidisciplinary Sciences

WDR5 modulates cell motility and morphology and controls nuclear changes induced by a 3D environment

Pengbo Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Vertical Light Sheet Enhanced Side-View Imaging for AFM Cell Mechanics Studies

Kellie Beicker et al.

SCIENTIFIC REPORTS (2018)

Article Nanoscience & Nanotechnology

Characterizing cellular mechanical phenotypes with mechano-node-pore sensing

Junghyun Kim et al.

MICROSYSTEMS & NANOENGINEERING (2018)

Article Cell Biology

Mechanical principles of nuclear shaping and positioning

Tanmay P. Lele et al.

JOURNAL OF CELL BIOLOGY (2018)

Article Cell Biology

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors

Yuntao Xia et al.

JOURNAL OF CELL BIOLOGY (2018)

Article Biochemical Research Methods

Localized mechanical stimulation of single cells with engineered spatio-temporal profile

M. Monticelli et al.

LAB ON A CHIP (2018)

Article Multidisciplinary Sciences

Curvotaxis directs cell migration through cell-scale curvature landscapes

Laurent Pieuchot et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton

Qiao Zhang et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2018)

Review Biophysics

Chromatin as a nuclear spring

Kazuhiro Maeshima et al.

BIOPHYSICS AND PHYSICOBIOLOGY (2018)

Article Biochemistry & Molecular Biology

Mechanics in human fibroblasts and progeria: Lamin A mutation E145K results in stiffening of nuclei

Ketaki Apte et al.

JOURNAL OF MOLECULAR RECOGNITION (2017)

Review Cell Biology

Mechanosensing by the nucleus: From pathways to scaling relationships

Sangkyun Cho et al.

JOURNAL OF CELL BIOLOGY (2017)

Article Cell Biology

Nucleosome-nucleosome interactions via histone tails and linker DNA regulate nuclear rigidity

Yuta Shimamoto et al.

MOLECULAR BIOLOGY OF THE CELL (2017)

Article Cell Biology

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

Andrew D. Stephens et al.

MOLECULAR BIOLOGY OF THE CELL (2017)

Review Cell Biology

Bursting the Bubble - Nuclear Envelope Rupture as a Path to Genomic Instability?

Pragya Shah et al.

TRENDS IN CELL BIOLOGY (2017)

Article Multidisciplinary Sciences

Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

Jeong-Ki Kim et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Machine Learning for Nuclear Mechano-Morphometric Biomarkers in Cancer Diagnosis

Adityanarayanan Radhakrishnan et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Atomic Force Microscopy microrheology reveals large structural inhomogeneities in single cellnuclei

Michael Lherbette et al.

SCIENTIFIC REPORTS (2017)

Article Nanoscience & Nanotechnology

Nonmonotonic Self-Deformation of Cell Nuclei on Topological Surfaces with Micropillar Array

Xiangnan Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Article Biophysics

3D Protein Dynamics in the Cell Nucleus

Anand P. Singh et al.

BIOPHYSICAL JOURNAL (2017)

Article Biochemistry & Molecular Biology

DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration

Jerome Irianto et al.

CURRENT BIOLOGY (2017)

Article Multidisciplinary Sciences

Nuclear deformability and telomere dynamics are regulated by cell geometric constraints

Ekta Makhija et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Physics, Applied

Poroelasticity of cell nuclei revealed through atomic force microscopy characterization

Fanan Wei et al.

APPLIED PHYSICS LETTERS (2016)

Article Biochemistry & Molecular Biology

The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation

Balazs Enyedi et al.

Article Cell & Tissue Engineering

An Unresolved LINC in the Nuclear Envelope

Mehdi Torbati et al.

CELLULAR AND MOLECULAR BIOENGINEERING (2016)

Review Cell Biology

Squish and squeeze - the nucleus as a physical barrier during migration in confined environments

Alexandra Lynn McGregor et al.

CURRENT OPINION IN CELL BIOLOGY (2016)

Article Cell Biology

Nuclear constriction segregates mobile nuclear proteins away from chromatin

Jerome Irianto et al.

MOLECULAR BIOLOGY OF THE CELL (2016)

Article Chemistry, Physical

Transcription upregulation via force-induced direct stretching of chromatin

Arash Tajik et al.

NATURE MATERIALS (2016)

Article Multidisciplinary Sciences

Nuclear envelope rupture and repair during cancer cell migration

Celine M. Denais et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Extracellular Forces Cause the Nucleus to Deform in a Highly Controlled Anisotropic Manner

Kristina Haase et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

Biomechanics of subcellular structures by non-invasive Brillouin microscopy

Giuseppe Antonacci et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

Multiparameter mechanical and morphometric screening of cells

Mahdokht Masaeli et al.

Scientific Reports (2016)

Article Cell Biology

Volume regulation and shape bifurcation in the cell nucleus

Dong-Hwee Kim et al.

JOURNAL OF CELL SCIENCE (2015)

Article Physics, Condensed Matter

The viscoelastic properties of chromatin and the nucleoplasm revealed by scale-dependent protein mobility

Fabian Erdel et al.

JOURNAL OF PHYSICS-CONDENSED MATTER (2015)

Article Biochemical Research Methods

Real-time deformability cytometry: on-the-fly cell mechanical phenotyping

Oliver Otto et al.

NATURE METHODS (2015)

Article Nanoscience & Nanotechnology

Vertical nanopillars for in situ probing of nuclear mechanics in adherent cells

Lindsey Hanson et al.

NATURE NANOTECHNOLOGY (2015)

Article Multidisciplinary Sciences

Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell

Srujana Neelam et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

The tethering of chromatin to the nuclear envelope supports nuclear mechanics

Sarah M. Schreiner et al.

NATURE COMMUNICATIONS (2015)

Article Multidisciplinary Sciences

Screening cell mechanotype by parallel microfiltration

Dongping Qi et al.

SCIENTIFIC REPORTS (2015)

Article Chemistry, Multidisciplinary

In Situ Mechanical Characterization of the Cell Nucleus by Atomic Force Microscopy

Haijiao Liu et al.

ACS NANO (2014)

Article Biophysics

Vimentin Enhances Cell Elastic Behavior and Protects against Compressive Stress

M. G. Mendez et al.

BIOPHYSICAL JOURNAL (2014)

Article Cell & Tissue Engineering

Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

Patricia M. Davidson et al.

CELLULAR AND MOLECULAR BIOENGINEERING (2014)

Article Cell Biology

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

Takamasa Harada et al.

JOURNAL OF CELL BIOLOGY (2014)

Article Cell Biology

Tight coupling between nucleus and cell migration through the perinuclear actin cap

Dong-Hwee Kim et al.

JOURNAL OF CELL SCIENCE (2014)

Article Cell Biology

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

Christophe Guilluy et al.

NATURE CELL BIOLOGY (2014)

Article Biochemical Research Methods

Dual-view plane illumination microscopy for rapid and spatially isotropic imaging

Abhishek Kumar et al.

NATURE PROTOCOLS (2014)

Review Optics

Adaptive optical microscopy: the ongoing quest for a perfect image

Martin J. Booth

LIGHT-SCIENCE & APPLICATIONS (2014)

Article Cell & Tissue Engineering

Modulation of Nuclear Shape by Substrate Rigidity

David B. Lovett et al.

CELLULAR AND MOLECULAR BIOENGINEERING (2013)

Article Biochemistry & Molecular Biology

Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling

Monika Zwerger et al.

HUMAN MOLECULAR GENETICS (2013)

Article Biochemistry & Molecular Biology

Nuclear Envelope Composition Determines the Ability of Neutrophil-type Cells to Passage through Micron-scale Constrictions

Amy C. Rowat et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Probing the compressibility of tumor cell nuclei by combined atomic force-confocal microscopy

Marina Krause et al.

PHYSICAL BIOLOGY (2013)

Article Multidisciplinary Sciences

Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells

Jae-Won Shin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Micron-scale coherence in interphase chromatin dynamics

Alexandra Zidovska et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Characterizing deformability and surface friction of cancer cells

Sangwon Byun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction

Allison B. Chambliss et al.

SCIENTIFIC REPORTS (2013)

Article Chemistry, Analytical

Microfluidics-Based Assessment of Cell Deformability

Andrea Adamo et al.

ANALYTICAL CHEMISTRY (2012)

Review Oncology

Nuclear lamins and laminopathies

Howard J. Worman

JOURNAL OF PATHOLOGY (2012)

Article Biochemical Research Methods

Nuclear deformation during breast cancer cell transmigration

Yi Fu et al.

LAB ON A CHIP (2012)

Article Multidisciplinary Sciences

Hydrodynamic stretching of single cells for large population mechanical phenotyping

Daniel R. Gossett et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Genetics & Heredity

Nuclear lamin functions and disease

Veronika Butin-Israeli et al.

TRENDS IN GENETICS (2012)

Article Biochemistry & Molecular Biology

Osmotic stress alters chromatin condensation and nucleocytoplasmic transport

John D. Finan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Biochemistry & Molecular Biology

Keeping the LINC: the importance of nucleocytoskeletal coupling in intracellular force transmission and cellular function

Maria L. Lombardi et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2011)

Article Biophysics

Biophysical Regulation of Histone Acetylation in Mesenchymal Stem Cells

Yuan Li et al.

BIOPHYSICAL JOURNAL (2011)

Review Radiology, Nuclear Medicine & Medical Imaging

An Overview of Elastography-An Emerging Branch of Medical Imaging

Armen Sarvazyan et al.

CURRENT MEDICAL IMAGING (2011)

Article Biotechnology & Applied Microbiology

Quantitative fluorescence imaging of protein diffusion and interaction in living cells

Jeremie Capoulade et al.

NATURE BIOTECHNOLOGY (2011)

Review Multidisciplinary Sciences

A Perspective on Cancer Cell Metastasis

Christine L. Chaffer et al.

SCIENCE (2011)

Article Engineering, Biomedical

Nuclear morphology and deformation in engineered cardiac myocytes and tissues

Mark-Anthony P. Bray et al.

BIOMATERIALS (2010)

Article Cell Biology

Mitotic chromosomes are constrained by topoisomerase II-sensitive DNA entanglements

Ryo Kawamura et al.

JOURNAL OF CELL BIOLOGY (2010)

Article Cell Biology

Efficient cell migration requires global chromatin condensation

Gabi Gerlitz et al.

JOURNAL OF CELL SCIENCE (2010)

Article Biochemistry & Molecular Biology

The Effects of Osmotic Stress on the Structure and Function of the Cell Nucleus

John D. Finan et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2010)

Article Multidisciplinary Sciences

In vivo pair correlation analysis of EGFP intranuclear diffusion reveals DNA-dependent molecular flow

Elizabeth Hinde et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Cell Biology

The perinuclear actin cap in health and disease

Shyam B. Khatau et al.

NUCLEUS (2010)

Article Engineering, Biomedical

Nonlinear Osmotic Properties of the Cell Nucleus

John D. Finan et al.

ANNALS OF BIOMEDICAL ENGINEERING (2009)

Article Biophysics

Particle-Tracking Microrheology of Living Cells: Principles and Applications

Denis Wirtz

Annual Review of Biophysics (2009)

Article Multidisciplinary Sciences

Mapping eGFP Oligomer Mobility in Living Cell Nuclei

Nicolas Dross et al.

PLOS ONE (2009)

Article Multidisciplinary Sciences

A perinuclear actin cap regulates nuclear shape

Shyam B. Khatau et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Cell Biology

Collagen-based cell migration models in vitro and in vivo

Katarina Wolf et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2009)

Review Biochemistry & Molecular Biology

Towards an integrated understanding of the structure and mechanics of the cell nucleus

Amy C. Rowat et al.

BIOESSAYS (2008)

Review Cardiac & Cardiovascular Systems

Emerin and the nuclear lamina in muscle and cardiac disease

James M. Holaska

CIRCULATION RESEARCH (2008)

Review Cardiac & Cardiovascular Systems

Nuclear shape, mechanics, and mechanotransduction

Kris Noel Dahl et al.

CIRCULATION RESEARCH (2008)

Article Biochemical Research Methods

Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry

Michael J. Rosenbluth et al.

LAB ON A CHIP (2008)

Article Optics

Confocal Brillouin microscopy for three-dimensional mechanical imaging

Giuliano Scarcelli et al.

NATURE PHOTONICS (2008)

Article Multidisciplinary Sciences

Physical plasticity of the nucleus in stem cell differentiation

J. David Pajerowski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Engineering, Biomedical

Reconfigurable microfluidic integration of a dual-beam laser trap with biomedical applications

Bryan Lincoln et al.

BIOMEDICAL MICRODEVICES (2007)

Article Multidisciplinary Sciences

Magnetic microposts as an approach to apply forces to living cells

Nathan J. Sniadecki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Chemistry, Multidisciplinary

Direct observation of nanomechanical properties of chromatin in living cells

Anthony H. B. de Vries et al.

NANO LETTERS (2007)

Article Biophysics

Mechanics and deformation of the nucleus in micropipette aspiration experiment

Ashkan Vaziri et al.

JOURNAL OF BIOMECHANICS (2007)

Article Biophysics

Mechanical properties of the cell nucleus and the effect of emerin deficiency

A. C. Rowat et al.

BIOPHYSICAL JOURNAL (2006)

Article Biochemistry & Molecular Biology

Lamins A and C but not lamin B1 regulate nuclear mechanics

Jan Lammerding et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Matrix elasticity directs stem cell lineage specification

Adam J. Engler et al.

Article Materials Science, Multidisciplinary

Deformation of the cell nucleus under indentation: Mechanics and mechanisms

A. Vaziri et al.

JOURNAL OF MATERIALS RESEARCH (2006)

Article Multidisciplinary Sciences

Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome

Kris Noel Dahl et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Biochemical Research Methods

Deep tissue two-photon microscopy

F Helmchen et al.

NATURE METHODS (2005)

Review Multidisciplinary Sciences

Tissue cells feel and respond to the stiffness of their substrate

DE Discher et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

Prestress mediates force propagation into the nucleus

SH Hu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Medicine, Research & Experimental

Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction

J Lammerding et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

Article Multidisciplinary Sciences

Lamin A truncation in Hutchinson-Gilford progeria

A De Sandre-Giovannoli et al.

SCIENCE (2003)

Article Multidisciplinary Sciences

Cells lying on a bed of microneedles: An approach to isolate mechanical force

JL Tan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

Mitotic chromosomes are chromatin networks without a mechanically contiguous protein scaffold

MG Poirier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biophysics

Contribution of the nucleus to the mechanical properties of endothelial cells

N Caille et al.

JOURNAL OF BIOMECHANICS (2002)

Article Biophysics

The optical stretcher:: A novel laser tool to micromanipulate cells

J Guck et al.

BIOPHYSICAL JOURNAL (2001)

Article Physics, Multidisciplinary

Optical deformability of soft biological dielectrics

J Guck et al.

PHYSICAL REVIEW LETTERS (2000)

Article Biochemistry & Molecular Biology

Viscoelastic properties of the cell nucleus

F Guilak et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)

Article Biochemistry & Molecular Biology

Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial lipodystrophy

H Cao et al.

HUMAN MOLECULAR GENETICS (2000)

Article Cell Biology

Reversible and irreversible unfolding of mitotic newt chromosomes by applied force

M Poirier et al.

MOLECULAR BIOLOGY OF THE CELL (2000)