期刊
CLINICAL AND EXPERIMENTAL REPRODUCTIVE MEDICINE-CERM
卷 49, 期 1, 页码 49-56出版社
KOREAN SOC REPRODUCTIVE MEDICINE
DOI: 10.5653/cerm.2021.04910
关键词
Centrum; Coenzyme Q10; Idiopathic oligoasthenozoospermia; Oxidative stress
This study compared the effects of coenzyme Q10 (CoQ10) and Centrum multivitamins on semen parameters, antioxidant capacity, and sperm DNA fragmentation (SDF) in infertile men with idiopathic oligoasthenospermia (OA). The results showed that both CoQ10 and Centrum improved semen parameters, antioxidant capacity, and SDF, but Centrum had greater improvement compared to CoQ10. Therefore, Centrum may be more effective in treating infertile men with idiopathic OA compared to individual antioxidants like CoQ10.
Objective: Oxidative stress and sperm DNA fragmentation (SDF) have been linked to idiopathic male infertility (IMI). Various antioxidants have been tried to improve semen parameters and fertility potential in IMI patients, but with inconsistent results. The study aimed to cornpare the effects of coenzyme Q10 (CoQ10) and Centrum multivitamins on semen parameters, seminal antioxidant capacity, and SDF in infertile men with idiopathic oligoasthenospermia (OA). Methods: This prospective controlled clinical study involved 130 patients with idiopathic OA and 58 fertile controls. The patients were divided randomly into two groups: the first group received CoQ10 (200 mg/day orally) and the second group received Centrum multivitamins (1 tablet/day) for 3 months. Semen parameters, CoQ10 levels, reactive oxygen species (ROS), total antioxidant capacity (TAC), catalase, SDF, and serum hormone levels (follicle-stimulating hormone, luteinizing hormone, testosterone, and prolactin) were compared at baseline and after 3 months. Results: Both CoQ10 and Centrum improved sperm concentration and motility, but the improvement was greater with Centrum therapy (p<0.05). Similarly, both therapies improved antioxidant capacity, but TAC and catalase improvement was greater (p<0.01 and p<0.001 respectively) with CoQ10, whereas ROS (p<0.01) and SDF (p<0.001) improvements were greater with Centrum administration. Centrum therapy was associated with reduced serum testosterone (p<0.05). Conclusion: In conclusion, both CoQ10 and Centrum were effective in improving semen parameters, antioxidant capacity, and SDF, but the improvement was greater with Centrum than with CoQ10. Therefore, Centrum-as a source of combined antioxidants-may provide more effective results than individual antioxidants such as CoQ10 in the treatment of infertile men with idiopathic OA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据