3.8 Article

Effects of an low carbohydrate/healthy fat/ketogenic diet on biomarkers of health and symptoms, anxiety and depression in Parkinson's disease: a pilot study

期刊

NEURODEGENERATIVE DISEASE MANAGEMENT
卷 12, 期 2, 页码 57-66

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FUTURE MEDICINE LTD
DOI: 10.2217/nmt-2021-0033

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anxiety; depression; ketogenic diet; metabolic disease; nutrition; Parkinson's disease; symptoms of Parkinson's disease

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Evaluated the effects of a low carbohydrate/healthy fat/ketogenic diet on adults with Parkinson's disease. Showed positive trends in biomarkers and anxiety symptoms, but further research is needed.
Aim: To evaluate a low carbohydrate/healthy fat/ketogenic diet (LCHF/KD) on symptoms, depression, anxiety and biomarkers in adults with Parkinson's disease (PD). Patients & methods: 16 adults ages 36-80 with PD participated in the intervention for 12 weeks. The study provided pre-post-study comparisons of biomarkers, weight, waist measurement, united Parkinson's Disease Rating Scale (UPDRS), Parkinson's Anxiety Scale (PAS) and Center for Epidemiologic Studies Depression Scale Revised-20 (CESD-R-20) Depression Scale. Results: Although LCHF/KD improves blood glucose in diabetes and seizure control in epilepsy, research gaps exist in this dietary intervention in PD. Statistically, significant improvements occurred in several measurements, PAS scores and Part I of the UPDRS. Conclusion: The LCHF/KD shows positive trends with improvements in biomarkers and anxiety symptoms. Further research is needed to evaluate dietary interventions for PD.

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