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Review
Immunology
Monica Fung et al.
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has led to significant morbidity and mortality globally. The impact of the disease on immunosuppressed patients, such as cancer patients and transplant recipients, remains unclear. Further research is needed to determine the risk of COVID-19 severity and death in immunocompromised patients.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Olivia S. Kates et al.
Summary: The mortality rate among SOT recipients hospitalized for COVID-19 was 20.5%, with age and underlying comorbidities being the major drivers of mortality, rather than measures related to immunosuppression intensity.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Surgery
Elisabeth Coll et al.
Summary: This study reported the experience of solid organ and hematopoietic stem cell transplant recipients diagnosed with COVID-19 in Spain until July 13, 2020. The incidence of COVID-19 in transplant recipients was higher than the general population. Most patients required hospitalization, and adjusting immunosuppression could improve survival rates. Risk factors for death included age, lung transplantation, and hospital-acquired COVID-19.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Berta Saez-Gimenez et al.
Summary: This study investigated the clinical presentation, treatment, and outcomes of SARS-CoV-2 infection in lung transplant recipients. The multicenter retrospective study found a high mortality rate among lung transplant recipients with SARS-CoV-2 infection, with key factors like initial disease severity predicting subsequent mortality.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Pratima Sharma et al.
Summary: Solid organ transplant recipients are vulnerable to COVID-19 infection due to immunosuppression. This study compared the outcomes of COVID-19 between SOT recipients and their matched nontransplant controls, finding similar rates of severe disease and short-term death but higher risk for renal replacement therapy in SOT patients. Hydroxychloroquine treatment for COVID-19 in SOT recipients was associated with high mortality, warranting further scrutiny of its role as a treatment modality.
Article
Critical Care Medicine
James C. Doidge et al.
Summary: The study described trends in intensive care for patients with COVID-19 and found significant variations in ICU admission rates during the first wave of the epidemic in England and Northern Ireland, varying over time and geography. Patient characteristics, care processes, and outcomes in ICU also changed, with some deviations in trends during the peak period. After adjusting for important risk factors, there was a substantial improvement in patient outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Medicine, General & Internal
George L. Anesi et al.
Summary: This study examined the epidemiology of COVID-19-related critical illness in the United States, specifically focusing on patients admitted to intensive care units within the University of Pennsylvania Health System. The results showed a decrease in mortality over time, despite stable patient characteristics. Further research is needed to confirm these findings and explore potential causal mechanisms.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Immunology
Jose Silvano et al.
Summary: Limited knowledge exists on the impact of COVID-19 on kidney transplant recipients, but severe cases show prolonged viral shedding and stronger antibody response. Further studies and longer follow-up are needed to confirm these preliminary findings.
TRANSPLANTATION PROCEEDINGS
(2021)
Review
Immunology
Mohammed A. Raja et al.
Summary: A systematic review and meta-analysis of SOT recipients with SARS-CoV-2 infection revealed a high hospital admission rate and mortality rate. Common symptoms included fever and cough, with the majority of recipients requiring hospital treatment. Use of immunosuppressive medications decreased, while treatments varied.
TRANSPLANTATION REVIEWS
(2021)
Review
Immunology
Arta Karruli et al.
Summary: The study suggests that continuing immune suppression in SOTR with COVID-19 may be safe and beneficial, especially with tacrolimus. Age and specific drug use were predictors of mortality, while immune suppression maintenance and tacrolimus continuation were predictors of survival.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Immunology
Yousaf B. Hadi et al.
Summary: Solid organ transplant recipients have a higher risk of hospitalization and acute kidney injury in COVID-19, but this increased risk is mainly due to a higher burden of comorbidities.
Article
Cardiac & Cardiovascular Systems
Manish R. Mohanka et al.
Summary: This study showed that compared to patients with RSV, those with COVID-19 were more likely to present with constitutional symptoms, decline in lung function, pulmonary opacities, new or worsening respiratory failure, and need for ventilator support. Patients with SARS-CoV-2 infection were less likely to receive a multimodality treatment strategy and experienced worse post-infection outcomes, including lung function loss, functional decline, and three-month survival.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Immunology
Marcus R. Pereira et al.
Summary: The study found that solid organ transplant recipients hospitalized with COVID-19 had similar overall outcomes as non-transplant patients, suggesting that chronic immunosuppression may not be an independent risk factor for poor outcomes in COVID-19.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Immunology
Marina P. Cristelli et al.
Summary: This study confirms a high 28-day fatality rate of COVID-19 among kidney transplant recipients, with age and comorbidities being primary factors. Allograft dysfunction was frequently observed with a variety of histologic lesions and high rates of complications and graft loss. Seroconversion was common among survivors and the persistence of viral shedding requires further investigation.
Article
Medicine, General & Internal
Sameer S. Kadri et al.
Summary: A retrospective cohort study conducted on COVID-19 patients from 558 U.S. hospitals between March and August 2020 found a significant increase in COVID-19 mortality rate with higher surge index percentiles, with the highest mortality rate observed in the 99th percentile and above. The study also revealed that despite increased use of corticosteroids and more judicious intubation in later months, the surge-mortality relationship was stronger in June to August compared to March to May.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Immunology
Nitipong Permpalung et al.
Summary: The impact of COVID-19 on lung transplant recipients remains unknown. This study found that LTRs with COVID-19 were more likely to develop decline in lung allograft function, secondary infections, and require rehospitalization compared to controls. There were no acute rejection episodes observed within 90 days post infection. Further research is needed to determine if LTRs who do not recover baseline lung function within 90 days may progress to chronic lung allograft dysfunction.
Article
Immunology
Jonathan Messika et al.
Summary: The COVID-19 infection in the French cohort of lung transplant patients was severe, with most cases requiring hospitalization and a survival rate of 85.7%. Among the critically ill patients, invasive mechanical ventilation was required for over half, and thrombotic events occurred in 4 patients. Overweight was significantly associated with the risk of death.
Article
Medicine, General & Internal
Leora Horwitz et al.
Summary: A study in a three-hospital academic health system in New York showed a decrease in hospital mortality rates among COVID-19 patients, with adjusted mortality dropping from 25.6% in March to 7.6% in August. The standardized mortality ratio also decreased from 1.26 in March to 0.38 in August, indicating an improving trend in patient outcomes. These findings suggest that mortality from COVID-19 may be decreasing even after adjusting for patient characteristics.
JOURNAL OF HOSPITAL MEDICINE
(2021)
Article
Surgery
Rogier A. S. Hoek et al.
TRANSPLANT INTERNATIONAL
(2020)
Letter
Medicine, General & Internal
Enver Akalin et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Surgery
Meghan Aversa et al.
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Surgery
Monica Fung et al.
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Surgery
Zohra S. Chaudhry et al.
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Surgery
Ilies Benotmane et al.
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Letter
Critical Care Medicine
Sara C. Auld et al.
CRITICAL CARE MEDICINE
(2020)
Review
Immunology
Catherine N. Myers et al.
TRANSPLANT INFECTIOUS DISEASE
(2020)
Article
Immunology
Stephanie G. Yi et al.
Review
Health Care Sciences & Services
Arunmozhimaran Elavarasi et al.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2020)
Article
Immunology
Anna M. Acosta et al.
OPEN FORUM INFECTIOUS DISEASES
(2020)
