期刊
CURRENT DEVELOPMENTS IN NUTRITION
卷 5, 期 12, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1093/cdn/nzab141
关键词
global burden of disease; iodine; iron; micronutrient; prevalence; vitamin A; zinc; deficiency
资金
- Bill & Melinda Gates Foundation [INV-003021]
Assessing the global prevalence of micronutrient deficiencies requires valid biomarkers and representative survey data, which are often lacking. Current estimates rely on complex statistical modeling using assumptions and proxies, potentially underestimating the extent of deficiencies and global health burden.
Information on the prevalence of micronutrient deficiencies is needed to determine related disease burden; underpin evidence-based advocacy; and design, deliver, and monitor safe, effective interventions. Assessing the global prevalence of deficiency requires a valid micronutrient status biomarker with an appropriate cutoff to define deficiency and relevant data from representative surveys across multiple locations and years. The Global Burden of Disease Study includes prevalence estimates for iodine, iron, zinc, and vitamin A deficiencies, for which recommended biomarkers and appropriate deficiency cutoffs exist. Because representative survey data are lacking, only retinol concentration is used to model vitamin A deficiency, and proxy indicators are used for the other micronutrients (goiter for iodine, hemoglobin for iron, and dietary food adequacy for zinc). Because of data limitations, complex statistical modeling is required to produce current estimates, relying on assumptions and proxies that likely understate the extent of micronutrient deficiencies and the consequent global health burden.
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