Anticancer Activity of Elytraria acaulis L. Extracts on T pie Negative Breast Cancer Cell Line

Objectives: In the present study, the anticancer potential of the plant extracts of Elytraria acaulis L. (E. acaulis L.) were investigated on human breast cancer cells (MDAMB-231). Methods: Different organic solvent extracts of E. acaulis L. were prepared using methanol, ethanol, ethyl acetate and hexane. The cytotoxicity of plant extracts were evaluated by MTT assay (-(4, 5-Dimethylthiazol-2-y1)-2,5-Diphenyltetrazolium Bromide) against MDA MB-231cells. The apoptosis associated morphological changes were also observed with the help of propidium iodide staining method. Results: Of all the solvent extracts, methanol extract has shown the highest activity and its IC50 concentration was found to be 80.8 +/- 2.08 mu g/ml. The anticancer drug Cis-diammineplatinum (II) dichloride was considered as a standard. Conclusion: In further the bioactive compound should be isolated from the methanol crude extract, which is responsible for the cytotoxic effects.

Automated summary

The study investigated the anticancer potential of extracts from Elytraria acaulis L. on human breast cancer cells. The methanol extract showed the highest activity, with an IC50 concentration of 80.8 +/- 2.08 µg/ml. Further research should focus on isolating the bioactive compound responsible for the cytotoxic effects.